SRGN [The Human Chemical-Genetic Interaction Map Project]

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======= SRGN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRGN
  * **<color #00a2e8>Official Name</color>**: serglycin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5552|5552]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10124|P10124]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRGN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRGN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/177040|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF- alpha and may also regulate protease secretion. Inhibits bone mineralization. {ECO:0000269|PubMed:11911826, ECO:0000269|PubMed:16420477, ECO:0000269|PubMed:16870619}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Serglycin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maintenance of protease location in T cell secretory granule|
|maintenance of protein location in T cell secretory granule|
|maintenance of protease location in mast cell secretory granule|
|protease localization to mast cell secretory granule|
|protein localization to T cell secretory granule|
|protein localization to mast cell secretory granule|
|T cell secretory granule organization|
|maintenance of protein location in mast cell secretory granule|
|maintenance of granzyme B location in T cell secretory granule|
|granzyme B localization to T cell secretory granule|
|protease localization to T cell secretory granule|
|mast cell secretory granule organization|
|protein localization to secretory granule|
|granzyme-mediated apoptotic signaling pathway|
|negative regulation of bone mineralization|
|mast cell granule|
|negative regulation of biomineralization|
|negative regulation of biomineral tissue development|
|secretory granule organization|
|platelet alpha granule lumen|
|negative regulation of cytokine secretion|
|negative regulation of ossification|
|regulation of bone mineralization|
|regulation of biomineral tissue development|
|biomineral tissue development|
|regulation of biomineralization|
|biomineralization|
|maintenance of location in cell|
|maintenance of protein location|
|platelet degranulation|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|protein processing|
|maintenance of location|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of ossification|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|protein maturation|
|negative regulation of secretion|
|negative regulation of cytokine production|
|apoptotic signaling pathway|
|vesicle organization|
|endomembrane system organization|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of cytokine production|
|regulated exocytosis|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|apoptotic process|
|negative regulation of developmental process|
|Golgi apparatus|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|programmed cell death|
|cell death|
|secretion|
|negative regulation of multicellular organismal process|
|proteolysis|
|cellular protein localization|
|extracellular space|
|cellular macromolecule localization|
|tissue development|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18399
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRGN Expression in NALM6 Cells: 1.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>