SRGN

Gene Information

Official Symbol: SRGN
Official Name: serglycin
Aliases and Previous Symbols: N/A
Entrez ID: 5552
UniProt: P10124
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF- alpha and may also regulate protease secretion. Inhibits bone mineralization. {ECO:0000269|PubMed:11911826, ECO:0000269|PubMed:16420477, ECO:0000269|PubMed:16870619}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18399
Expression level (log2 read counts): 1.74

Expression Distribution

maintenance of protease location in T cell secretory granule
maintenance of protein location in T cell secretory granule
maintenance of protease location in mast cell secretory granule
protease localization to mast cell secretory granule
protein localization to T cell secretory granule
protein localization to mast cell secretory granule
T cell secretory granule organization
maintenance of protein location in mast cell secretory granule
maintenance of granzyme B location in T cell secretory granule
granzyme B localization to T cell secretory granule
protease localization to T cell secretory granule
mast cell secretory granule organization
protein localization to secretory granule
granzyme-mediated apoptotic signaling pathway
negative regulation of bone mineralization
mast cell granule
negative regulation of biomineralization
negative regulation of biomineral tissue development
secretory granule organization
platelet alpha granule lumen
negative regulation of cytokine secretion
negative regulation of ossification
regulation of bone mineralization
regulation of biomineral tissue development
biomineral tissue development
regulation of biomineralization
biomineralization
maintenance of location in cell
maintenance of protein location
platelet degranulation
negative regulation of protein secretion
negative regulation of peptide secretion
protein processing
maintenance of location
negative regulation of protein transport
negative regulation of establishment of protein localization
regulation of ossification
negative regulation of secretion by cell
regulation of cytokine secretion
protein maturation