SRI
Gene Information
- Official Symbol: SRI
- Official Name: sorcin
- Aliases and Previous Symbols: N/A
- Entrez ID: 6717
- UniProt: P30626
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012].
- UniProt Summary: Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. {ECO:0000269|PubMed:17699613}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| dendritic spine neck |
| chromaffin granule membrane |
| intracellular sequestering of iron ion |
| negative regulation of cardiac muscle contraction |
| sequestering of iron ion |
| negative regulation of striated muscle contraction |
| regulation of cell communication by electrical coupling involved in cardiac conduction |
| regulation of relaxation of muscle |
| negative regulation of heart rate |
| negative regulation of ryanodine-sensitive calcium-release channel activity |
| sequestering of metal ion |
| regulation of cell communication by electrical coupling |
| negative regulation of release of sequestered calcium ion into cytosol |
| regulation of high voltage-gated calcium channel activity |
| positive regulation of sequestering of calcium ion |
| cytoplasmic sequestering of transcription factor |
| negative regulation of calcium ion transport into cytosol |
| negative regulation of transcription regulatory region DNA binding |
| negative regulation of muscle contraction |
| negative regulation of heart contraction |
| cytoplasmic sequestering of protein |
| regulation of ryanodine-sensitive calcium-release channel activity |
| smooth endoplasmic reticulum |
| regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| negative regulation of calcium-mediated signaling |
| sarcoplasmic reticulum membrane |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| negative regulation of blood circulation |
| regulation of voltage-gated calcium channel activity |
| negative regulation of calcium ion transmembrane transporter activity |
| calcium channel regulator activity |
| regulation of cardiac muscle cell contraction |
| negative regulation of calcium ion transmembrane transport |
| repressing transcription factor binding |
| positive regulation of release of sequestered calcium ion into cytosol |
| regulation of actin filament-based movement |
| negative regulation of cation channel activity |
| T-tubule |
| sarcoplasmic reticulum |
| axon terminus |
| regulation of transcription regulatory region DNA binding |
| positive regulation of calcium ion transport into cytosol |
| negative regulation of DNA binding |
| regulation of insulin secretion involved in cellular response to glucose stimulus |
| negative regulation of calcium ion transport |
| cellular iron ion homeostasis |
| regulation of cardiac conduction |
| positive regulation of calcium ion transmembrane transport |
| negative regulation of ion transmembrane transporter activity |
| positive regulation of insulin secretion |
| regulation of cardiac muscle contraction |
| regulation of release of sequestered calcium ion into cytosol |
| negative regulation of transporter activity |
| iron ion homeostasis |
| negative regulation of cation transmembrane transport |
| regulation of calcium ion transmembrane transporter activity |
| regulation of striated muscle contraction |
| action potential |
| negative regulation of ion transmembrane transport |
| maintenance of location in cell |
| regulation of heart rate |
| regulation of calcium-mediated signaling |
| positive regulation of peptide hormone secretion |
| regulation of calcium ion transport into cytosol |
| protease binding |
| maintenance of protein location |
| cellular transition metal ion homeostasis |
| negative regulation of transmembrane transport |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| regulation of DNA binding |
| ion channel binding |
| positive regulation of hormone secretion |
| transition metal ion homeostasis |
| Z disc |
| positive regulation of cation transmembrane transport |
| regulation of calcium ion transmembrane transport |
| negative regulation of ion transport |
| positive regulation of ion transmembrane transport |
| negative regulation of DNA-binding transcription factor activity |
| regulation of muscle contraction |
| maintenance of location |
| negative regulation of binding |
| regulation of cation channel activity |
| regulation of insulin secretion |
| positive regulation of transmembrane transport |
| regulation of peptide hormone secretion |
| regulation of muscle system process |
| regulation of heart contraction |
| regulation of calcium ion transport |
| calcium ion transport |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| positive regulation of ion transport |
| regulation of transporter activity |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| positive regulation of peptide secretion |
| divalent metal ion transport |
| muscle organ development |
| divalent inorganic cation transport |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| signaling receptor binding |
| regulation of binding |
| regulation of metal ion transport |
| regulation of actin filament-based process |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| regulation of DNA-binding transcription factor activity |
| regulation of membrane potential |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| muscle structure development |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| protein heterodimerization activity |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| negative regulation of intracellular signal transduction |
| heart development |
| regulation of hormone levels |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| regulation of system process |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| regulation of ion transport |
| regulation of protein transport |
| cation homeostasis |
| inorganic ion homeostasis |
| calcium ion binding |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| ion homeostasis |
| regulation of secretion |
| cation transport |
| circulatory system development |
| cellular homeostasis |
| regulation of cellular localization |
| endoplasmic reticulum membrane |
| positive regulation of transport |
| regulation of cellular component movement |
| regulation of protein localization |
| chemical homeostasis |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| mitochondrion |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| ion transport |
| negative regulation of response to stimulus |
| homeostatic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| TRAIL 50ng/ml R00 exp36 | 1.94 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17318
- Expression level (log2 read counts): 5.9
Expression Distribution
SRI Expression in NALM6 Cells: 5.9
