SRM [The Human Chemical-Genetic Interaction Map Project]

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======= SRM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRM
  * **<color #00a2e8>Official Name</color>**: spermidine synthase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6723|6723]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19623|P19623]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182891|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine. {ECO:0000269|PubMed:17585781}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Spermine synth|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spermidine synthase activity|
|spermidine biosynthetic process|
|spermidine metabolic process|
|polyamine biosynthetic process|
|polyamine metabolic process|
|cellular biogenic amine biosynthetic process|
|amine biosynthetic process|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|amine metabolic process|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|ammonium ion metabolic process|
|protein homodimerization activity|
|cellular response to cytokine stimulus|
|identical protein binding|
|response to cytokine|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.48|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.96|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.81|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.75|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.71|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.73|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.73|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.73|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.74|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.75|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.76|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.76|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.77|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.79|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.8|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.82|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.84|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.89|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.92|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.94|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.95|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.96|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.97|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.99|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|2.02|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.05|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.06|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.06|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.06|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.09|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.11|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.12|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.22|
|[[:results:exp461|BS-181 20μM R08 exp461]]|2.23|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.24|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.26|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.35|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.36|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.36|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.36|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.37|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.39|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.39|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.4|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.44|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.44|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.46|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.48|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.49|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.49|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.53|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.53|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2.56|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.6|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.66|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.8|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.82|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.83|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.84|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|3.04|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|3.11|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|3.17|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|3.19|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|3.36|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.47|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|3.62|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|3.64|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|3.65|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|3.72|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.89|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|4.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.446|
|[[:human genes:o:odc1|ODC1]]|0.437|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1542
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRM Expression in NALM6 Cells: 6.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>