SRM

Gene Information

Official Symbol: SRM
Official Name: spermidine synthase
Aliases and Previous Symbols: N/A
Entrez ID: 6723
UniProt: P19623
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine. {ECO:0000269|PubMed:17585781}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MS023 2μM R03 exp134	-2.48
A-196 10μM R03 exp114	-1.96
PNU96415E 10μM R03 exp145	-1.81
Hydroxychloroquine 30μM R08 exp490	-1.75
Rotenone 0.07μM R08 exp431	1.71
GSK-J4 1.5μM R08 exp441	1.73
Monensin 0.3μM R08 exp507	1.73
Resveratrol 16μM R03 exp147	1.73
Deferoxamine 11μM R07 exp350	1.74
TIC10 10μM R08 exp532	1.75
Methotrexate 0.01μM R08 exp501	1.76
SNS-032 15μM R08 exp443	1.76
Mitomycin-C 0.06μM R08 exp503	1.77
Nutlin-3A 1.6μM R06 exp294	1.79
UMK57 1μM R01 exp59	1.8
Ribavirin 10 to 15μM on day4 R04 exp160	1.82
JQ1 0.8μM R08 exp435	1.84
PU-H71 1μM R08 exp515	1.89
LLY-283 2.6μM R06 exp290	1.92
Pterostilbene 16μM R02 exp78	1.94
3-Bromopyruvate 7μM R04 exp175	1.95
Q15 1 to 2μM on day4 R04 exp164	1.96
Centrinone 0.5μM R07 exp343	1.97
UM131593 0.2μM R03 exp106	1.99
Trichostatin-A 0.06μM R07 exp415	2.02
MK2206 4μM R08 exp504	2.05
Benzoate 10000μM R08 exp455	2.06
Citral 75μM R06 exp275	2.06
Docetaxel 0.002μM R01 exp45	2.06
Thapsigargin 0.005μM R07 exp407	2.09
Hydroxyurea 100μM R07 exp329	2.11
Rucaparib 6.5μM R08 exp520	2.12
Dinaciclib 0.007μM R07 exp355	2.22
BS-181 20μM R08 exp461	2.23
AICAR 240μM R05 exp211	2.24
GSK591 2.6μM R03 exp128	2.26
ML-792 0.2μM R08 exp505	2.35
Aminopterin 0.005μM R07 exp335	2.36
Cytochalasin-B 5μM R07 exp349	2.36
MLN-4924 0.2μM R00 exp21	2.36
Bleomycin 5μM R08 exp459	2.37
Aphidicolin 0.4μM R08 exp440	2.39
BI-6727 0.0125μM R03 exp97	2.39
Tubacin 1.6μM R07 exp416	2.4
Latrunculin-B 10μM R07 exp374	2.44
Olaparib 4μM R08 exp512	2.44
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.46
Hippuristanol 0.12μM R08 exp488	2.48
Cannabidiol 20μM R08 exp466	2.49
Cryptotanshinone 12μM R05 exp227	2.49
Bafilomycin-A1 0.009μM R08 exp454	2.53
HMS-I1 10μM R06 exp256	2.53
All-trans-Retinoic-Acid 40μM R07 exp334	2.56
BML-284 0.09μM R08 exp460	2.6
RO-3307 4.7μM R02 exp80	2.66
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.8
Vemurafenib 6.6μM R08 exp434	2.82
ETC-159 50μM R08 exp480	2.83
GSK626616 14μM R08 exp485	2.84
Docosahexaenoic-acid 50μM R07 exp356	3.04
Thimerosal 0.85μM R08 exp529	3.11
Staurosporine 0.02μM R08 exp524	3.17
Ethanol 0.01 R05 exp234	3.19
CB-5083 0.4μM R08 exp468	3.36
LY2090314 0.003μM R08 exp499	3.47
Sulforaphane 9μM R08 exp526 no dilution day6	3.62
Sulforaphane 9μM R08 exp525	3.64
Diepoxybutane 3μM R07 exp354	3.65
LY2090314 0.003μM R08 exp500 no dilution day6	3.72
Arsenate 40μM R06 exp264	3.89
Bortezomib 0.005μM R00 exp6	4.1

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1542
Expression level (log2 read counts): 6.65

Expression Distribution

Gene	Correlation
PRIM1	0.446
ODC1	0.437

spermidine synthase activity
spermidine biosynthetic process
spermidine metabolic process
polyamine biosynthetic process
polyamine metabolic process
cellular biogenic amine biosynthetic process
amine biosynthetic process
cellular biogenic amine metabolic process
cellular amine metabolic process
amine metabolic process
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
ammonium ion metabolic process
protein homodimerization activity
cellular response to cytokine stimulus
identical protein binding
response to cytokine
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process