SRP14 [The Human Chemical-Genetic Interaction Map Project]

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======= SRP14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRP14
  * **<color #00a2e8>Official Name</color>**: signal recognition particle 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6727|6727]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P37108|P37108]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRP14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRP14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600708|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SRP14|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endoplasmic reticulum signal peptide binding|
|signal recognition particle, endoplasmic reticulum targeting|
|7S RNA binding|
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|secretory granule lumen|
|ficolin-1-rich granule lumen|
|protein localization to endoplasmic reticulum|
|protein targeting to membrane|
|establishment of protein localization to membrane|
|protein targeting|
|establishment of protein localization to organelle|
|protein localization to membrane|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|protein localization to organelle|
|leukocyte mediated immunity|
|exocytosis|
|leukocyte activation|
|intracellular protein transport|
|secretion by cell|
|response to drug|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.31|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.2|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.08|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-2.02|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.01|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.95|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.9|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.76|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.74|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.72|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.71|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.71|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.7|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.71|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.75|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.8|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.91|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.95|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.12|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.13|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.18|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.25|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.3|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.41|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|3.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.671|
|[[:human genes:p:pmm2|PMM2]]|0.641|
|[[:human genes:d:dpagt1|DPAGT1]]|0.637|
|[[:human genes:t:triap1|TRIAP1]]|0.634|
|[[:human genes:a:alg1|ALG1]]|0.631|
|[[:human genes:g:gmppb|GMPPB]]|0.607|
|[[:human genes:r:rtcb|RTCB]]|0.602|
|[[:human genes:a:atxn10|ATXN10]]|0.597|
|[[:human genes:r:rpe|RPE]]|0.593|
|[[:human genes:u:uap1|UAP1]]|0.593|
|[[:human genes:c:crls1|CRLS1]]|0.576|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.575|
|[[:human genes:a:adsl|ADSL]]|0.574|
|[[:human genes:d:dhrsx|DHRSX]]|0.572|
|[[:human genes:r:rabggtb|RABGGTB]]|0.57|
|[[:human genes:r:rptor|RPTOR]]|0.569|
|[[:human genes:g:gfpt1|GFPT1]]|0.567|
|[[:human genes:r:romo1|ROMO1]]|0.564|
|[[:human genes:h:hars|HARS]]|0.564|
|[[:human genes:d:dohh|DOHH]]|0.564|
|[[:human genes:g:gemin8|GEMIN8]]|0.561|
|[[:human genes:r:rnmt|RNMT]]|0.56|
|[[:human genes:t:ten1|TEN1]]|0.559|
|[[:human genes:s:slc25a26|SLC25A26]]|0.556|
|[[:human genes:t:taz|TAZ]]|0.556|
|[[:human genes:p:ppa2|PPA2]]|0.554|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.553|
|[[:human genes:r:rpia|RPIA]]|0.552|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.551|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.55|
|[[:human genes:a:alg13|ALG13]]|0.55|
|[[:human genes:a:alg6|ALG6]]|0.549|
|[[:human genes:u:uhrf1|UHRF1]]|0.547|
|[[:human genes:n:nae1|NAE1]]|0.544|
|[[:human genes:d:dhps|DHPS]]|0.544|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.543|
|[[:human genes:l:lsm10|LSM10]]|0.543|
|[[:human genes:t:tkt|TKT]]|0.543|
|[[:human genes:p:ppcs|PPCS]]|0.533|
|[[:human genes:a:atp2a2|ATP2A2]]|0.532|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.531|
|[[:human genes:c:chchd4|CHCHD4]]|0.53|
|[[:human genes:t:tsen54|TSEN54]]|0.527|
|[[:human genes:c:cep57|CEP57]]|0.527|
|[[:human genes:u:utp23|UTP23]]|0.521|
|[[:human genes:d:dad1|DAD1]]|0.521|
|[[:human genes:b:bap1|BAP1]]|0.521|
|[[:human genes:v:vezt|VEZT]]|0.518|
|[[:human genes:e:exoc4|EXOC4]]|0.517|
|[[:human genes:p:pik3r4|PIK3R4]]|0.516|
|[[:human genes:a:atic|ATIC]]|0.514|
|[[:human genes:u:ube2g2|UBE2G2]]|0.514|
|[[:human genes:h:hspd1|HSPD1]]|0.513|
|[[:human genes:g:gnb1l|GNB1L]]|0.512|
|[[:human genes:e:eif3f|EIF3F]]|0.511|
|[[:human genes:d:dr1|DR1]]|0.511|
|[[:human genes:a:apaf1|APAF1]]|0.51|
|[[:human genes:f:fh|FH]]|0.51|
|[[:human genes:e:eno1|ENO1]]|0.509|
|[[:human genes:r:rpp21|RPP21]]|0.508|
|[[:human genes:b:bak1|BAK1]]|0.503|
|[[:human genes:d:dnlz|DNLZ]]|0.5|
|[[:human genes:c:cbfb|CBFB]]|0.5|
|[[:human genes:u:urm1|URM1]]|0.5|
|[[:human genes:t:tpi1|TPI1]]|0.5|
|[[:human genes:h:hccs|HCCS]]|0.5|
|[[:human genes:n:nsmce1|NSMCE1]]|0.499|
|[[:human genes:t:tamm41|TAMM41]]|0.499|
|[[:human genes:p:pelo|PELO]]|0.499|
|[[:human genes:c:c14orf80|C14orf80]]|0.498|
|[[:human genes:k:kdsr|KDSR]]|0.498|
|[[:human genes:a:alg5|ALG5]]|0.497|
|[[:human genes:m:mbtps2|MBTPS2]]|0.497|
|[[:human genes:s:srd5a3|SRD5A3]]|0.495|
|[[:human genes:s:sec62|SEC62]]|0.494|
|[[:human genes:m:mtor|MTOR]]|0.494|
|[[:human genes:m:med16|MED16]]|0.494|
|[[:human genes:t:tbca|TBCA]]|0.494|
|[[:human genes:e:elp3|ELP3]]|0.494|
|[[:human genes:s:snapc5|SNAPC5]]|0.491|
|[[:human genes:a:aars|AARS]]|0.491|
|[[:human genes:p:pggt1b|PGGT1B]]|0.491|
|[[:human genes:t:trmt5|TRMT5]]|0.49|
|[[:human genes:s:slc25a19|SLC25A19]]|0.49|
|[[:human genes:d:dolk|DOLK]]|0.489|
|[[:human genes:p:ppp4c|PPP4C]]|0.488|
|[[:human genes:p:ppp6c|PPP6C]]|0.488|
|[[:human genes:p:pgm3|PGM3]]|0.487|
|[[:human genes:t:tprkb|TPRKB]]|0.486|
|[[:human genes:t:tpk1|TPK1]]|0.486|
|[[:human genes:g:gemin7|GEMIN7]]|0.486|
|[[:human genes:e:eny2|ENY2]]|0.484|
|[[:human genes:g:gemin6|GEMIN6]]|0.483|
|[[:human genes:e:exoc3|EXOC3]]|0.483|
|[[:human genes:e:eprs|EPRS]]|0.479|
|[[:human genes:t:tti1|TTI1]]|0.478|
|[[:human genes:d:ddx20|DDX20]]|0.477|
|[[:human genes:t:trmt10a|TRMT10A]]|0.476|
|[[:human genes:e:eif4e|EIF4E]]|0.474|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.474|
|[[:human genes:t:tubd1|TUBD1]]|0.473|
|[[:human genes:n:n6amt1|N6AMT1]]|0.472|
|[[:human genes:c:c15orf41|C15orf41]]|0.472|
|[[:human genes:t:taf1a|TAF1A]]|0.472|
|[[:human genes:l:lsm11|LSM11]]|0.469|
|[[:human genes:r:rad1|RAD1]]|0.468|
|[[:human genes:r:rft1|RFT1]]|0.467|
|[[:human genes:s:srp9|SRP9]]|0.467|
|[[:human genes:d:ddost|DDOST]]|0.467|
|[[:human genes:b:bcs1l|BCS1L]]|0.466|
|[[:human genes:t:tti2|TTI2]]|0.465|
|[[:human genes:w:wdr24|WDR24]]|0.465|
|[[:human genes:k:kctd5|KCTD5]]|0.464|
|[[:human genes:c:cdipt|CDIPT]]|0.461|
|[[:human genes:f:faf2|FAF2]]|0.46|
|[[:human genes:n:nbn|NBN]]|0.459|
|[[:human genes:p:pdap1|PDAP1]]|0.459|
|[[:human genes:c:cct7|CCT7]]|0.458|
|[[:human genes:h:haus8|HAUS8]]|0.458|
|[[:human genes:o:osgep|OSGEP]]|0.457|
|[[:human genes:a:atp5j|ATP5J]]|0.456|
|[[:human genes:u:uba5|UBA5]]|0.455|
|[[:human genes:a:alg2|ALG2]]|0.455|
|[[:human genes:t:trmt61a|TRMT61A]]|0.453|
|[[:human genes:t:timm13|TIMM13]]|0.452|
|[[:human genes:p:pgk1|PGK1]]|0.452|
|[[:human genes:c:ctc1|CTC1]]|0.451|
|[[:human genes:u:ube2m|UBE2M]]|0.45|
|[[:human genes:r:rad50|RAD50]]|0.45|
|[[:human genes:p:plaa|PLAA]]|0.45|
|[[:human genes:o:opa1|OPA1]]|0.45|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.45|
|[[:human genes:s:ssb|SSB]]|0.448|
|[[:human genes:g:gemin5|GEMIN5]]|0.447|
|[[:human genes:c:casp9|CASP9]]|0.447|
|[[:human genes:b:bub3|BUB3]]|0.445|
|[[:human genes:t:ttc4|TTC4]]|0.445|
|[[:human genes:t:trnt1|TRNT1]]|0.444|
|[[:human genes:d:ddx55|DDX55]]|0.443|
|[[:human genes:u:uba3|UBA3]]|0.443|
|[[:human genes:t:tmem41b|TMEM41B]]|0.44|
|[[:human genes:o:oraov1|ORAOV1]]|0.439|
|[[:human genes:c:cmtr1|CMTR1]]|0.439|
|[[:human genes:u:uxt|UXT]]|0.439|
|[[:human genes:a:alg8|ALG8]]|0.438|
|[[:human genes:m:med4|MED4]]|0.437|
|[[:human genes:p:pkm|PKM]]|0.437|
|[[:human genes:p:polr3h|POLR3H]]|0.437|
|[[:human genes:a:alg14|ALG14]]|0.436|
|[[:human genes:t:tmed10|TMED10]]|0.436|
|[[:human genes:p:pdpk1|PDPK1]]|0.435|
|[[:human genes:m:mrps33|MRPS33]]|0.435|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.434|
|[[:human genes:d:dpf2|DPF2]]|0.433|
|[[:human genes:s:sec63|SEC63]]|0.432|
|[[:human genes:t:tbp|TBP]]|0.431|
|[[:human genes:t:trmt6|TRMT6]]|0.43|
|[[:human genes:z:zrsr2|ZRSR2]]|0.43|
|[[:human genes:m:mrps5|MRPS5]]|0.43|
|[[:human genes:s:sars2|SARS2]]|0.43|
|[[:human genes:c:ccdc101|CCDC101]]|0.43|
|[[:human genes:t:tbcb|TBCB]]|0.429|
|[[:human genes:t:telo2|TELO2]]|0.429|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.429|
|[[:human genes:t:timm22|TIMM22]]|0.427|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.426|
|[[:human genes:d:dusp12|DUSP12]]|0.424|
|[[:human genes:n:naa20|NAA20]]|0.424|
|[[:human genes:d:ddx42|DDX42]]|0.424|
|[[:human genes:c:cycs|CYCS]]|0.423|
|[[:human genes:d:ddx1|DDX1]]|0.423|
|[[:human genes:r:rbmx2|RBMX2]]|0.423|
|[[:human genes:s:snf8|SNF8]]|0.423|
|[[:human genes:p:pam16|PAM16]]|0.423|
|[[:human genes:p:ppcdc|PPCDC]]|0.422|
|[[:human genes:c:csnk2b|CSNK2B]]|0.422|
|[[:human genes:s:sec61g|SEC61G]]|0.422|
|[[:human genes:g:ggps1|GGPS1]]|0.421|
|[[:human genes:f:fnta|FNTA]]|0.42|
|[[:human genes:r:rbfa|RBFA]]|0.419|
|[[:human genes:t:tube1|TUBE1]]|0.418|
|[[:human genes:c:ciao1|CIAO1]]|0.418|
|[[:human genes:v:vdac2|VDAC2]]|0.418|
|[[:human genes:c:c1d|C1D]]|0.416|
|[[:human genes:y:yars2|YARS2]]|0.416|
|[[:human genes:p:pgs1|PGS1]]|0.416|
|[[:human genes:s:srprb|SRPRB]]|0.415|
|[[:human genes:p:ptar1|PTAR1]]|0.415|
|[[:human genes:v:vrk1|VRK1]]|0.415|
|[[:human genes:t:txnl4b|TXNL4B]]|0.414|
|[[:human genes:p:psmg4|PSMG4]]|0.414|
|[[:human genes:g:gtf3a|GTF3A]]|0.413|
|[[:human genes:e:elac2|ELAC2]]|0.412|
|[[:human genes:w:wdr92|WDR92]]|0.412|
|[[:human genes:c:c16orf59|C16orf59]]|0.411|
|[[:human genes:z:znhit1|ZNHIT1]]|0.411|
|[[:human genes:a:atp5a1|ATP5A1]]|0.411|
|[[:human genes:n:ncor1|NCOR1]]|0.411|
|[[:human genes:d:dhdds|DHDDS]]|0.409|
|[[:human genes:t:tgs1|TGS1]]|0.409|
|[[:human genes:c:cept1|CEPT1]]|0.408|
|[[:human genes:e:eef1e1|EEF1E1]]|0.408|
|[[:human genes:m:mrps6|MRPS6]]|0.407|
|[[:human genes:t:tomm40|TOMM40]]|0.406|
|[[:human genes:r:rfk|RFK]]|0.406|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.405|
|[[:human genes:u:ube2k|UBE2K]]|0.404|
|[[:human genes:e:ercc2|ERCC2]]|0.403|
|[[:human genes:s:sdha|SDHA]]|0.402|
|[[:human genes:w:wdr1|WDR1]]|0.402|
|[[:human genes:t:tma16|TMA16]]|0.401|
|[[:human genes:l:lmo2|LMO2]]|0.401|
|[[:human genes:u:ube2j1|UBE2J1]]|0.4|
|[[:human genes:g:gatc|GATC]]|0.4|
|[[:human genes:e:elp2|ELP2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 690/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|25/28|
|bone|25/26|
|breast|30/33|
|central nervous system|52/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|69/75|
|lymphocyte|14/16|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3781
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRP14 Expression in NALM6 Cells: 7.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>