SRP14

Gene Information

Official Symbol: SRP14
Official Name: signal recognition particle 14
Aliases and Previous Symbols: N/A
Entrez ID: 6727
UniProt: P37108
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0131023 0.05μM R05 exp248	-2.31
NFN1 0.1μM R01 exp49	-2.2
IU1-47 25μM R04 exp182	-2.08
BAY-598 4μM R05 exp220	-2.02
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.01
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.95
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.9
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.76
DABN 2μM R00 exp16	-1.74
Geldanamycin 0.01μM R05 exp235	-1.72
Ibrutinib 1μM R07 exp372	-1.71
RO-3306 3 to 4μM on day4 R04 exp165	-1.71
Cidofovir 10μM R07 exp345	-1.7
GSK461364A 0.1μM R03 exp126	1.71
Arsenate 40μM R06 exp264	1.75
ONC212 0.15μM R08 exp513	1.8
PU-H71 1μM R08 exp515	1.91
THZ1 0.06μM R08 exp531	1.95
Staurosporine 0.02μM R08 exp524	2.12
Latrunculin-B 10μM R07 exp374	2.13
Ammonium tetrathiomolybdate 10μM R08 exp448	2.18
Hinokiflavone 12μM R08 exp487	2.25
SNS-032 15μM R08 exp443	2.3
Milciclib 2μM R08 exp502	2.41
Cytochalasin-B 5μM R07 exp349	3.13

Gene	Correlation
THG1L	0.671
PMM2	0.641
DPAGT1	0.637
TRIAP1	0.634
ALG1	0.631
GMPPB	0.607
RTCB	0.602
ATXN10	0.597
RPE	0.593
UAP1	0.593
CRLS1	0.576
GTF3C4	0.575
ADSL	0.574
DHRSX	0.572
RABGGTB	0.57
RPTOR	0.569
GFPT1	0.567
ROMO1	0.564
HARS	0.564
DOHH	0.564
GEMIN8	0.561
RNMT	0.56
TEN1	0.559
SLC25A26	0.556
TAZ	0.556
PPA2	0.554
PPP2R3C	0.553
RPIA	0.552
GTF3C3	0.551
GTF3C6	0.55
ALG13	0.55
ALG6	0.549
UHRF1	0.547
NAE1	0.544
DHPS	0.544
GTF3C2	0.543
LSM10	0.543
TKT	0.543
PPCS	0.533
ATP2A2	0.532
AASDHPPT	0.531
CHCHD4	0.53
TSEN54	0.527
CEP57	0.527
UTP23	0.521
DAD1	0.521
BAP1	0.521
VEZT	0.518
EXOC4	0.517
PIK3R4	0.516
ATIC	0.514
UBE2G2	0.514
HSPD1	0.513
GNB1L	0.512
EIF3F	0.511
DR1	0.511
APAF1	0.51
FH	0.51
ENO1	0.509
RPP21	0.508
BAK1	0.503
DNLZ	0.5
CBFB	0.5
URM1	0.5
TPI1	0.5
HCCS	0.5
NSMCE1	0.499
TAMM41	0.499
PELO	0.499
C14orf80	0.498
KDSR	0.498
ALG5	0.497
MBTPS2	0.497
SRD5A3	0.495
SEC62	0.494
MTOR	0.494
MED16	0.494
TBCA	0.494
ELP3	0.494
SNAPC5	0.491
AARS	0.491
PGGT1B	0.491
TRMT5	0.49
SLC25A19	0.49
DOLK	0.489
PPP4C	0.488
PPP6C	0.488
PGM3	0.487
TPRKB	0.486
TPK1	0.486
GEMIN7	0.486
ENY2	0.484
GEMIN6	0.483
EXOC3	0.483
EPRS	0.479
TTI1	0.478
DDX20	0.477
TRMT10A	0.476
EIF4E	0.474
GTF2A2	0.474
TUBD1	0.473
N6AMT1	0.472
C15orf41	0.472
TAF1A	0.472
LSM11	0.469
RAD1	0.468
RFT1	0.467
SRP9	0.467
DDOST	0.467
BCS1L	0.466
TTI2	0.465
WDR24	0.465
KCTD5	0.464
CDIPT	0.461
FAF2	0.46
NBN	0.459
PDAP1	0.459
CCT7	0.458
HAUS8	0.458
OSGEP	0.457
ATP5J	0.456
UBA5	0.455
ALG2	0.455
TRMT61A	0.453
TIMM13	0.452
PGK1	0.452
CTC1	0.451
UBE2M	0.45
RAD50	0.45
PLAA	0.45
OPA1	0.45
SUPV3L1	0.45
SSB	0.448
GEMIN5	0.447
CASP9	0.447
BUB3	0.445
TTC4	0.445
TRNT1	0.444
DDX55	0.443
UBA3	0.443
TMEM41B	0.44
ORAOV1	0.439
CMTR1	0.439
UXT	0.439
ALG8	0.438
MED4	0.437
PKM	0.437
POLR3H	0.437
ALG14	0.436
TMED10	0.436
PDPK1	0.435
MRPS33	0.435
FGFR1OP	0.434
DPF2	0.433
SEC63	0.432
TBP	0.431
TRMT6	0.43
ZRSR2	0.43
MRPS5	0.43
SARS2	0.43
CCDC101	0.43
TBCB	0.429
TELO2	0.429
CTDNEP1	0.429
TIMM22	0.427
LAMTOR4	0.426
DUSP12	0.424
NAA20	0.424
DDX42	0.424
CYCS	0.423
DDX1	0.423
RBMX2	0.423
SNF8	0.423
PAM16	0.423
PPCDC	0.422
CSNK2B	0.422
SEC61G	0.422
GGPS1	0.421
FNTA	0.42
RBFA	0.419
TUBE1	0.418
CIAO1	0.418
VDAC2	0.418
C1D	0.416
YARS2	0.416
PGS1	0.416
SRPRB	0.415
PTAR1	0.415
VRK1	0.415
TXNL4B	0.414
PSMG4	0.414
GTF3A	0.413
ELAC2	0.412
WDR92	0.412
C16orf59	0.411
ZNHIT1	0.411
ATP5A1	0.411
NCOR1	0.411
DHDDS	0.409
TGS1	0.409
CEPT1	0.408
EEF1E1	0.408
MRPS6	0.407
TOMM40	0.406
RFK	0.406
HSD17B10	0.405
UBE2K	0.404
ERCC2	0.403
SDHA	0.402
WDR1	0.402
TMA16	0.401
LMO2	0.401
UBE2J1	0.4
GATC	0.4
ELP2	0.4

Global Fraction of Cell Lines Where Essential: 690/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	25/28
bone	25/26
breast	30/33
central nervous system	52/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	20/21
liver	20/20
lung	69/75
lymphocyte	14/16
ovary	25/26
pancreas	23/24
peripheral nervous system	15/16
plasma cell	13/15
prostate	0/1
skin	23/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	28/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 3781
Expression level (log2 read counts): 7.01

Expression Distribution

endoplasmic reticulum signal peptide binding
signal recognition particle, endoplasmic reticulum targeting
7S RNA binding
SRP-dependent cotranslational protein targeting to membrane
cotranslational protein targeting to membrane
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
secretory granule lumen
ficolin-1-rich granule lumen
protein localization to endoplasmic reticulum
protein targeting to membrane
establishment of protein localization to membrane
protein targeting
establishment of protein localization to organelle
protein localization to membrane
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
protein localization to organelle
leukocyte mediated immunity
exocytosis
leukocyte activation
intracellular protein transport
secretion by cell
response to drug
export from cell
cell activation
immune effector process
secretion
RNA binding
protein transport