SRPX [The Human Chemical-Genetic Interaction Map Project]

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======= SRPX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRPX
  * **<color #00a2e8>Official Name</color>**: sushi repeat containing protein X-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8406|8406]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78539|P78539]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRPX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRPX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300187|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HYR|
|Sushi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cell proliferation involved in contact inhibition|
|contact inhibition|
|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|phagolysosome assembly|
|phagosome maturation|
|regulation of extrinsic apoptotic signaling pathway in absence of ligand|
|positive regulation of extrinsic apoptotic signaling pathway|
|lysosome organization|
|lytic vacuole organization|
|autophagosome|
|vacuole organization|
|extracellular matrix structural constituent|
|regulation of extrinsic apoptotic signaling pathway|
|positive regulation of apoptotic signaling pathway|
|response to endoplasmic reticulum stress|
|process utilizing autophagic mechanism|
|autophagy|
|vesicle organization|
|phagocytosis|
|collagen-containing extracellular matrix|
|regulation of apoptotic signaling pathway|
|cell surface|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|organelle assembly|
|cell adhesion|
|biological adhesion|
|endoplasmic reticulum|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.8|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.78|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.74|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.7|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.73|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.76|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.78|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.79|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.8|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14576
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRPX Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>