SRPX

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 2μM R07 exp306	-1.8
RK-33 8μM R08 exp518	-1.78
FK-506 5μM R07 exp358	-1.74
Dimethyl-Sulfoxide 1pc R03 exp120	1.7
Rapamycin 0.001μM R08 exp429	1.73
Nutlin-3A 1.6μM R06 exp294	1.76
QNZ 0.01μM R08 exp439	1.78
PT-1 25μM R07 exp392	1.79
Sulforaphane 9μM R08 exp526 no dilution day6	1.8
IL-3 9ng/ml R08 exp493	1.85

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

HYR
Sushi

negative regulation of cell proliferation involved in contact inhibition
contact inhibition
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
phagolysosome assembly
phagosome maturation
regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of extrinsic apoptotic signaling pathway
lysosome organization
lytic vacuole organization
autophagosome
vacuole organization
extracellular matrix structural constituent
regulation of extrinsic apoptotic signaling pathway
positive regulation of apoptotic signaling pathway
response to endoplasmic reticulum stress
process utilizing autophagic mechanism
autophagy
vesicle organization
phagocytosis
collagen-containing extracellular matrix
regulation of apoptotic signaling pathway
cell surface
positive regulation of apoptotic process
positive regulation of programmed cell death
negative regulation of cell population proliferation
positive regulation of cell death
organelle assembly
cell adhesion
biological adhesion
endoplasmic reticulum
regulation of apoptotic process
regulation of programmed cell death
regulation of cell population proliferation
positive regulation of signal transduction
regulation of cell death
cellular response to stress
cellular catabolic process
positive regulation of cell communication
positive regulation of signaling
vesicle-mediated transport