SRRM1 [The Human Chemical-Genetic Interaction Map Project]

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======= SRRM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRRM1
  * **<color #00a2e8>Official Name</color>**: serine and arginine repetitive matrix 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10250|10250]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IYB3|Q8IYB3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRRM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRRM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605975|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PWI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA 3-end processing|
|catalytic step 2 spliceosome|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|nuclear matrix|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|intracellular protein transport|
|RNA binding|
|DNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-2.19|
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.01|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.9|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.77|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.79|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.85|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.88|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.02|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.03|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 339/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|17/28|
|blood|6/28|
|bone|10/25|
|breast|21/33|
|central nervous system|26/56|
|cervix|0/4|
|colorectal|10/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|8/15|
|kidney|12/21|
|liver|10/20|
|lung|40/75|
|lymphocyte|10/14|
|ovary|11/26|
|pancreas|10/24|
|peripheral nervous system|11/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|4/7|
|thyroid|1/2|
|upper aerodigestive|6/22|
|urinary tract|14/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1414
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRRM1 Expression in NALM6 Cells: 7.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>