SRRM1

Entrez Summary: N/A
UniProt Summary: Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 339/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	17/28
blood	6/28
bone	10/25
breast	21/33
central nervous system	26/56
cervix	0/4
colorectal	10/17
esophagus	7/13
fibroblast	1/1
gastric	8/15
kidney	12/21
liver	10/20
lung	40/75
lymphocyte	10/14
ovary	11/26
pancreas	10/24
peripheral nervous system	11/16
plasma cell	7/15
prostate	1/1
skin	6/24
soft tissue	4/7
thyroid	1/2
upper aerodigestive	6/22
urinary tract	14/29
uterus	5/5

Expression Distribution

mRNA 3-end processing
catalytic step 2 spliceosome
mRNA export from nucleus
mRNA-containing ribonucleoprotein complex export from nucleus
nuclear matrix
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
RNA 3-end processing
protein export from nucleus
mRNA transport
nuclear export
nucleic acid transport
RNA transport
establishment of RNA localization
RNA localization
nucleobase-containing compound transport
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
nuclear speck
mRNA processing
mRNA metabolic process
RNA processing
intracellular protein transport
RNA binding
DNA binding
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
RNA metabolic process
establishment of localization in cell