SRSF9 [The Human Chemical-Genetic Interaction Map Project]

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======= SRSF9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRSF9
  * **<color #00a2e8>Official Name</color>**: serine and arginine rich splicing factor 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8683|8683]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13242|Q13242]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRSF9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRSF9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601943|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11875052, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:15009090, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:15695522, ECO:0000269|PubMed:7556075}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of mRNA splicing, via spliceosome|
|negative regulation of RNA splicing|
|negative regulation of mRNA processing|
|mRNA splice site selection|
|mRNA cis splicing, via spliceosome|
|spliceosomal complex assembly|
|regulation of alternative mRNA splicing, via spliceosome|
|negative regulation of mRNA metabolic process|
|mRNA 3-end processing|
|regulation of mRNA splicing, via spliceosome|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|response to alkaloid|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|regulation of RNA splicing|
|regulation of mRNA processing|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|ribonucleoprotein complex assembly|
|nucleobase-containing compound transport|
|protein domain specific binding|
|ribonucleoprotein complex subunit organization|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|RNA splicing|
|nuclear speck|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|response to toxic substance|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA processing|
|intracellular protein transport|
|response to organonitrogen compound|
|response to nitrogen compound|
|negative regulation of RNA metabolic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|negative regulation of gene expression|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.29|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7404
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRSF9 Expression in NALM6 Cells: 7.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>