SRSF9

Entrez Summary: N/A
UniProt Summary: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11875052, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611, ECO:0000269|PubMed:15009090, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:15695522, ECO:0000269|PubMed:7556075}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
TRAIL 50ng/ml R00 exp36	-2.29
Olaparib 4μM R08 exp512	-1.73

negative regulation of mRNA splicing, via spliceosome
negative regulation of RNA splicing
negative regulation of mRNA processing
mRNA splice site selection
mRNA cis splicing, via spliceosome
spliceosomal complex assembly
regulation of alternative mRNA splicing, via spliceosome
negative regulation of mRNA metabolic process
mRNA 3-end processing
regulation of mRNA splicing, via spliceosome
mRNA export from nucleus
mRNA-containing ribonucleoprotein complex export from nucleus
response to alkaloid
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
RNA 3-end processing
regulation of RNA splicing
regulation of mRNA processing
protein export from nucleus
mRNA transport
nuclear export
nucleic acid transport
RNA transport
establishment of RNA localization
RNA localization
ribonucleoprotein complex assembly
nucleobase-containing compound transport
protein domain specific binding
ribonucleoprotein complex subunit organization
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
regulation of mRNA metabolic process
RNA splicing
nuclear speck
ribonucleoprotein complex biogenesis