SSBP2 [The Human Chemical-Genetic Interaction Map Project]

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======= SSBP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SSBP2
  * **<color #00a2e8>Official Name</color>**: single stranded DNA binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23635|23635]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P81877|P81877]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SSBP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SSBP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607389|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene may be associated with survival in human glioblastoma patients. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SSDP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|single-stranded DNA binding|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2.11|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.05|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.95|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.92|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.86|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.79|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.72|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.71|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.74|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.92|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.14|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:ldb1|LDB1]]|0.654|
|[[:human genes:l:lmo2|LMO2]]|0.587|
|[[:human genes:c:cbfb|CBFB]]|0.568|
|[[:human genes:d:dohh|DOHH]]|0.547|
|[[:human genes:m:maml1|MAML1]]|0.542|
|[[:human genes:i:id3|ID3]]|0.541|
|[[:human genes:b:bap1|BAP1]]|0.537|
|[[:human genes:n:nsd1|NSD1]]|0.533|
|[[:human genes:r:rptor|RPTOR]]|0.523|
|[[:human genes:r:runx1|RUNX1]]|0.514|
|[[:human genes:z:zmym2|ZMYM2]]|0.498|
|[[:human genes:l:lyl1|LYL1]]|0.494|
|[[:human genes:z:zfx|ZFX]]|0.488|
|[[:human genes:t:trim33|TRIM33]]|0.486|
|[[:human genes:s:sox7|SOX7]]|0.483|
|[[:human genes:b:brpf1|BRPF1]]|0.475|
|[[:human genes:s:scaf8|SCAF8]]|0.475|
|[[:human genes:l:lef1|LEF1]]|0.469|
|[[:human genes:a:asxl2|ASXL2]]|0.468|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.467|
|[[:human genes:w:wdr24|WDR24]]|0.467|
|[[:human genes:r:rnmt|RNMT]]|0.465|
|[[:human genes:z:znf410|ZNF410]]|0.456|
|[[:human genes:c:ccdc101|CCDC101]]|0.455|
|[[:human genes:t:trmt10a|TRMT10A]]|0.449|
|[[:human genes:e:erg|ERG]]|0.445|
|[[:human genes:t:thg1l|THG1L]]|0.442|
|[[:human genes:m:mlst8|MLST8]]|0.442|
|[[:human genes:z:zmiz1|ZMIZ1]]|0.438|
|[[:human genes:x:xpo6|XPO6]]|0.438|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.436|
|[[:human genes:c:ctdspl2|CTDSPL2]]|0.434|
|[[:human genes:m:med16|MED16]]|0.434|
|[[:human genes:m:mtor|MTOR]]|0.433|
|[[:human genes:f:fli1|FLI1]]|0.426|
|[[:human genes:m:mapk14|MAPK14]]|0.425|
|[[:human genes:t:trnt1|TRNT1]]|0.421|
|[[:human genes:b:brd9|BRD9]]|0.42|
|[[:human genes:v:vhl|VHL]]|0.419|
|[[:human genes:p:polr3b|POLR3B]]|0.417|
|[[:human genes:a:atf7ip|ATF7IP]]|0.417|
|[[:human genes:d:dpagt1|DPAGT1]]|0.416|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.41|
|[[:human genes:u:ube3a|UBE3A]]|0.409|
|[[:human genes:t:taf5l|TAF5L]]|0.408|
|[[:human genes:r:rtcb|RTCB]]|0.407|
|[[:human genes:s:sec62|SEC62]]|0.407|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.406|
|[[:human genes:p:parl|PARL]]|0.406|
|[[:human genes:m:med23|MED23]]|0.404|
|[[:human genes:g:gltscr1l|GLTSCR1L]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8865
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SSBP2 Expression in NALM6 Cells: 7.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>