SSBP2

Entrez Summary: This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene may be associated with survival in human glioblastoma patients. [provided by RefSeq, Sep 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dexamethasone 0.006μM R07 exp351	-2.11
MK2206 4μM R08 exp504	-2.05
Pomalidomide 20μM R07 exp391	-1.95
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.92
Rapamycin 1μM R00 exp29	-1.86
LB-100 2μM R05 exp210	-1.79
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.72
Citral 50μM R06 exp274	-1.71
R-DABN 8μM R03 exp111	1.74
JQ1 0.8μM R08 exp435	1.92
LY2090314 0.003μM R08 exp499	2.14
LY2090314 0.003μM R08 exp500 no dilution day6	2.24

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

single-stranded DNA binding
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of transcription by RNA polymerase II
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process