SSH2 [The Human Chemical-Genetic Interaction Map Project]

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======= SSH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SSH2
  * **<color #00a2e8>Official Name</color>**: slingshot protein phosphatase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85464|85464]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q76I76|Q76I76]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SSH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SSH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606779|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DSPc|
|DEK C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphoprotein phosphatase activity|
|protein tyrosine/serine/threonine phosphatase activity|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|protein dephosphorylation|
|actin binding|
|dephosphorylation|
|cytoskeleton|
|actin cytoskeleton organization|
|actin filament-based process|
|cell morphogenesis|
|cellular component morphogenesis|
|cytoskeleton organization|
|extracellular space|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-3.14|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.35|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.15|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.93|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.72|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.72|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.565|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.563|
|[[:human genes:p:polr2j3|POLR2J3]]|0.554|
|[[:human genes:z:zfand5|ZFAND5]]|0.549|
|[[:human genes:d:dtl|DTL]]|0.546|
|[[:human genes:c:cbwd5|CBWD5]]|0.54|
|[[:human genes:s:supt6h|SUPT6H]]|0.538|
|[[:human genes:c:cbwd3|CBWD3]]|0.536|
|[[:human genes:p:psmb4|PSMB4]]|0.535|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.533|
|[[:human genes:p:psmd3|PSMD3]]|0.529|
|[[:human genes:n:nupl1|NUPL1]]|0.528|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.526|
|[[:human genes:d:ddtl|DDTL]]|0.522|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.52|
|[[:human genes:s:sec13|SEC13]]|0.513|
|[[:human genes:p:psmd1|PSMD1]]|0.512|
|[[:human genes:s:s1pr4|S1PR4]]|0.511|
|[[:human genes:p:psmb1|PSMB1]]|0.509|
|[[:human genes:s:slc38a7|SLC38A7]]|0.508|
|[[:human genes:m:mdm2|MDM2]]|0.508|
|[[:human genes:c:cdca3|CDCA3]]|0.507|
|[[:human genes:c:chd4|CHD4]]|0.505|
|[[:human genes:n:nbpf16|NBPF16]]|0.505|
|[[:human genes:p:psmd2|PSMD2]]|0.502|
|[[:human genes:r:rrn3|RRN3]]|0.5|
|[[:human genes:k:kctd17|KCTD17]]|0.5|
|[[:human genes:r:rad51|RAD51]]|0.498|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.498|
|[[:human genes:s:syt9|SYT9]]|0.496|
|[[:human genes:t:twistnb|TWISTNB]]|0.494|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.492|
|[[:human genes:n:nup188|NUP188]]|0.492|
|[[:human genes:c:cbwd6|CBWD6]]|0.491|
|[[:human genes:c:ccna2|CCNA2]]|0.49|
|[[:human genes:c:chmp2a|CHMP2A]]|0.482|
|[[:human genes:c:c14orf93|C14orf93]]|0.482|
|[[:human genes:p:psma6|PSMA6]]|0.481|
|[[:human genes:a:ahctf1|AHCTF1]]|0.479|
|[[:human genes:p:psmd11|PSMD11]]|0.479|
|[[:human genes:m:mt1e|MT1E]]|0.477|
|[[:human genes:v:vasn|VASN]]|0.475|
|[[:human genes:t:tceb3c|TCEB3C]]|0.475|
|[[:human genes:i:igfn1|IGFN1]]|0.473|
|[[:human genes:r:rbbp5|RBBP5]]|0.472|
|[[:human genes:t:trim52|TRIM52]]|0.472|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.471|
|[[:human genes:p:psmc1|PSMC1]]|0.471|
|[[:human genes:c:cdc45|CDC45]]|0.47|
|[[:human genes:p:pola2|POLA2]]|0.47|
|[[:human genes:t:tfip11|TFIP11]]|0.469|
|[[:human genes:r:rad21|RAD21]]|0.469|
|[[:human genes:o:orc6|ORC6]]|0.469|
|[[:human genes:r:rpl35|RPL35]]|0.468|
|[[:human genes:s:snrpa1|SNRPA1]]|0.466|
|[[:human genes:a:ankle2|ANKLE2]]|0.465|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.465|
|[[:human genes:l:lad1|LAD1]]|0.462|
|[[:human genes:r:rps7|RPS7]]|0.462|
|[[:human genes:m:myo1h|MYO1H]]|0.461|
|[[:human genes:r:rps2|RPS2]]|0.46|
|[[:human genes:h:hivep3|HIVEP3]]|0.46|
|[[:human genes:c:ctage4|CTAGE4]]|0.458|
|[[:human genes:s:slc4a1|SLC4A1]]|0.457|
|[[:human genes:w:wdr87|WDR87]]|0.456|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.456|
|[[:human genes:e:elmod3|ELMOD3]]|0.456|
|[[:human genes:o:orc1|ORC1]]|0.456|
|[[:human genes:c:copg1|COPG1]]|0.456|
|[[:human genes:n:nup54|NUP54]]|0.456|
|[[:human genes:h:hmgcr|HMGCR]]|0.455|
|[[:human genes:u:upf1|UPF1]]|0.454|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.454|
|[[:human genes:r:rilpl2|RILPL2]]|0.454|
|[[:human genes:s:smg1|SMG1]]|0.454|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.454|
|[[:human genes:z:znf106|ZNF106]]|0.454|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.454|
|[[:human genes:a:atp13a1|ATP13A1]]|0.453|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.453|
|[[:human genes:k:kpnb1|KPNB1]]|0.452|
|[[:human genes:t:ticrr|TICRR]]|0.452|
|[[:human genes:t:traip|TRAIP]]|0.451|
|[[:human genes:n:nup107|NUP107]]|0.451|
|[[:human genes:s:smg7|SMG7]]|0.45|
|[[:human genes:r:rpl6|RPL6]]|0.45|
|[[:human genes:p:pcf11|PCF11]]|0.449|
|[[:human genes:c:cdc73|CDC73]]|0.446|
|[[:human genes:d:ddx56|DDX56]]|0.446|
|[[:human genes:r:rps12|RPS12]]|0.445|
|[[:human genes:p:psmc6|PSMC6]]|0.445|
|[[:human genes:f:fbxw9|FBXW9]]|0.445|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.444|
|[[:human genes:n:nup160|NUP160]]|0.443|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.443|
|[[:human genes:a:aqr|AQR]]|0.443|
|[[:human genes:m:myo18a|MYO18A]]|0.443|
|[[:human genes:b:bysl|BYSL]]|0.441|
|[[:human genes:n:nup153|NUP153]]|0.441|
|[[:human genes:a:atxn1|ATXN1]]|0.44|
|[[:human genes:p:psmd7|PSMD7]]|0.439|
|[[:human genes:p:plk4|PLK4]]|0.438|
|[[:human genes:c:clasp1|CLASP1]]|0.438|
|[[:human genes:p:psap|PSAP]]|0.438|
|[[:human genes:g:golga8o|GOLGA8O]]|0.438|
|[[:human genes:r:rrp15|RRP15]]|0.438|
|[[:human genes:n:nbpf10|NBPF10]]|0.438|
|[[:human genes:l:loc643669|LOC643669]]|0.437|
|[[:human genes:c:chaf1a|CHAF1A]]|0.436|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.433|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.433|
|[[:human genes:n:nop16|NOP16]]|0.433|
|[[:human genes:c:cgb2|CGB2]]|0.433|
|[[:human genes:p:plk1|PLK1]]|0.432|
|[[:human genes:c:cacna1a|CACNA1A]]|0.432|
|[[:human genes:r:rps9|RPS9]]|0.432|
|[[:human genes:n:nol8|NOL8]]|0.431|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.431|
|[[:human genes:c:cdc6|CDC6]]|0.429|
|[[:human genes:n:npipb5|NPIPB5]]|0.428|
|[[:human genes:p:psmd6|PSMD6]]|0.426|
|[[:human genes:m:med17|MED17]]|0.426|
|[[:human genes:c:ccdc116|CCDC116]]|0.426|
|[[:human genes:a:acsf2|ACSF2]]|0.426|
|[[:human genes:f:fcn2|FCN2]]|0.426|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.425|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.425|
|[[:human genes:m:med29|MED29]]|0.424|
|[[:human genes:r:rps28|RPS28]]|0.423|
|[[:human genes:p:pan3|PAN3]]|0.422|
|[[:human genes:c:csnk1a1|CSNK1A1]]|0.421|
|[[:human genes:c:cwc22|CWC22]]|0.421|
|[[:human genes:c:cnot1|CNOT1]]|0.421|
|[[:human genes:p:pan2|PAN2]]|0.421|
|[[:human genes:a:ankle1|ANKLE1]]|0.42|
|[[:human genes:e:exosc9|EXOSC9]]|0.419|
|[[:human genes:p:pole|POLE]]|0.419|
|[[:human genes:a:aaas|AAAS]]|0.419|
|[[:human genes:r:riok2|RIOK2]]|0.419|
|[[:human genes:g:gosr2|GOSR2]]|0.419|
|[[:human genes:r:rnf121|RNF121]]|0.418|
|[[:human genes:d:dync1i2|DYNC1I2]]|0.418|
|[[:human genes:s:slc7a6os|SLC7A6OS]]|0.418|
|[[:human genes:f:fam86b2|FAM86B2]]|0.418|
|[[:human genes:p:paf1|PAF1]]|0.417|
|[[:human genes:c:cope|COPE]]|0.416|
|[[:human genes:s:scaf1|SCAF1]]|0.416|
|[[:human genes:d:ddt|DDT]]|0.416|
|[[:human genes:r:rsl1d1|RSL1D1]]|0.415|
|[[:human genes:s:sfpq|SFPQ]]|0.415|
|[[:human genes:i:iscu|ISCU]]|0.415|
|[[:human genes:w:wdr43|WDR43]]|0.415|
|[[:human genes:l:lrr1|LRR1]]|0.414|
|[[:human genes:c:ctr9|CTR9]]|0.413|
|[[:human genes:m:madcam1|MADCAM1]]|0.413|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.413|
|[[:human genes:p:pop1|POP1]]|0.412|
|[[:human genes:d:dhfr|DHFR]]|0.412|
|[[:human genes:r:rbm39|RBM39]]|0.412|
|[[:human genes:n:nol10|NOL10]]|0.412|
|[[:human genes:s:snrnp70|SNRNP70]]|0.411|
|[[:human genes:p:polr2f|POLR2F]]|0.411|
|[[:human genes:k:krt78|KRT78]]|0.41|
|[[:human genes:p:psma7|PSMA7]]|0.41|
|[[:human genes:g:golga8j|GOLGA8J]]|0.41|
|[[:human genes:r:rpl34|RPL34]]|0.409|
|[[:human genes:m:mat2a|MAT2A]]|0.409|
|[[:human genes:n:nup133|NUP133]]|0.408|
|[[:human genes:u:uqcrh|UQCRH]]|0.408|
|[[:human genes:v:vps54|VPS54]]|0.408|
|[[:human genes:s:srrm2|SRRM2]]|0.407|
|[[:human genes:g:golga8k|GOLGA8K]]|0.406|
|[[:human genes:c:cdh24|CDH24]]|0.405|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.405|
|[[:human genes:m:myt1l|MYT1L]]|0.405|
|[[:human genes:s:supt5h|SUPT5H]]|0.405|
|[[:human genes:m:med14|MED14]]|0.405|
|[[:human genes:n:nup85|NUP85]]|0.404|
|[[:human genes:r:rpsa|RPSA]]|0.403|
|[[:human genes:s:sult2b1|SULT2B1]]|0.402|
|[[:human genes:n:narfl|NARFL]]|0.402|
|[[:human genes:s:sf3a3|SF3A3]]|0.402|
|[[:human genes:r:ran|RAN]]|0.402|
|[[:human genes:r:rrp7a|RRP7A]]|0.402|
|[[:human genes:m:mms22l|MMS22L]]|0.402|
|[[:human genes:n:ndc1|NDC1]]|0.402|
|[[:human genes:t:tsg101|TSG101]]|0.402|
|[[:human genes:r:rad51c|RAD51C]]|0.401|
|[[:human genes:x:xylt2|XYLT2]]|0.401|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.401|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2029
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SSH2 Expression in NALM6 Cells: 7.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>