SSTR1

Entrez Summary: N/A
UniProt Summary: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
VHL-ligand-1 20μM R07 exp421	1.73
2-Methoxyestradiol 0.55μM R07 exp310	1.89

somatostatin receptor signaling pathway
somatostatin signaling pathway
somatostatin receptor activity
neuropeptide binding
cellular response to estradiol stimulus
glutamate receptor signaling pathway
peptide binding
response to leukemia inhibitory factor
cellular response to leukemia inhibitory factor
cerebellum development
neuropeptide signaling pathway
metencephalon development
response to estradiol
hindbrain development
hormone-mediated signaling pathway
response to starvation
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
forebrain development
response to nutrient levels
cellular response to lipid
response to extracellular stimulus
cellular response to organic cyclic compound
spermatogenesis
male gamete generation
cellular response to hormone stimulus
negative regulation of cell population proliferation
gamete generation
G protein-coupled receptor activity
brain development
head development
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
response to lipid
response to hormone
response to organic cyclic compound
central nervous system development
multi-organism reproductive process
cellular response to cytokine stimulus
cellular response to oxygen-containing compound