SSTR2

Gene Information

Official Symbol: SSTR2
Official Name: somatostatin receptor 2
Aliases and Previous Symbols: N/A
Entrez ID: 6752
UniProt: P30874
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. {ECO:0000269|PubMed:15231824, ECO:0000269|PubMed:18653781, ECO:0000269|PubMed:19434240, ECO:0000269|PubMed:22495673, ECO:0000269|PubMed:22932785}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12722
Expression level (log2 read counts): 4.61

Expression Distribution

7TM GPCR Srv
7tm 1
7TM GPCR Srx
7TM GPCR Srsx

somatostatin signaling pathway
somatostatin receptor activity
somatostatin receptor signaling pathway
peristalsis
phasic smooth muscle contraction
neuropeptide binding
cellular response to estradiol stimulus
peptide binding
smooth muscle contraction
cellular response to glucocorticoid stimulus
cellular response to corticosteroid stimulus
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
PDZ domain binding
cerebellum development
neuropeptide signaling pathway
metencephalon development
response to estradiol
response to glucocorticoid
hindbrain development
regulation of muscle contraction
response to corticosteroid
hormone-mediated signaling pathway
cellular response to steroid hormone stimulus
response to starvation
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
regulation of muscle system process
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
muscle contraction
muscle system process
response to steroid hormone
forebrain development
response to nutrient levels
cellular response to lipid
response to extracellular stimulus
cellular response to organic cyclic compound
spermatogenesis
male gamete generation
regulation of system process
cellular response to hormone stimulus
negative regulation of cell population proliferation