SSTR4 [The Human Chemical-Genetic Interaction Map Project]

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======= SSTR4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SSTR4
  * **<color #00a2e8>Official Name</color>**: somatostatin receptor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6754|6754]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31391|P31391]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SSTR4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SSTR4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182454|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srv|
|7TM GPCR Srsx|
|7TM GPCR Srw|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|somatostatin signaling pathway|
|somatostatin receptor signaling pathway|
|somatostatin receptor activity|
|positive regulation of arachidonic acid secretion|
|regulation of arachidonic acid secretion|
|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|positive regulation of icosanoid secretion|
|positive regulation of fatty acid transport|
|regulation of icosanoid secretion|
|neuropeptide binding|
|negative regulation of cAMP-mediated signaling|
|regulation of fatty acid transport|
|positive regulation of organic acid transport|
|negative regulation of G protein-coupled receptor signaling pathway|
|regulation of cAMP-mediated signaling|
|positive regulation of anion transport|
|peptide binding|
|cellular response to glucocorticoid stimulus|
|regulation of organic acid transport|
|cellular response to corticosteroid stimulus|
|positive regulation of lipid transport|
|positive regulation of lipid localization|
|regulation of anion transport|
|neuropeptide signaling pathway|
|regulation of lipid transport|
|regulation of lipid localization|
|regulation of G protein-coupled receptor signaling pathway|
|response to glucocorticoid|
|response to corticosteroid|
|hormone-mediated signaling pathway|
|cellular response to steroid hormone stimulus|
|positive regulation of ERK1 and ERK2 cascade|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|positive regulation of ion transport|
|regulation of ERK1 and ERK2 cascade|
|response to steroid hormone|
|forebrain development|
|positive regulation of secretion|
|negative regulation of intracellular signal transduction|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|cellular response to hormone stimulus|
|negative regulation of cell population proliferation|
|regulation of ion transport|
|G protein-coupled receptor activity|
|brain development|
|regulation of MAPK cascade|
|head development|
|regulation of secretion|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|cell migration|
|central nervous system development|
|positive regulation of transport|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|locomotion|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14629
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SSTR4 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>