SSTR4

Gene Information

Official Symbol: SSTR4
Official Name: somatostatin receptor 4
Aliases and Previous Symbols: N/A
Entrez ID: 6754
UniProt: P31391
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14629
Expression level (log2 read counts): -7.68

Expression Distribution

7tm 1
7TM GPCR Srv
7TM GPCR Srsx
7TM GPCR Srw

somatostatin signaling pathway
somatostatin receptor signaling pathway
somatostatin receptor activity
positive regulation of arachidonic acid secretion
regulation of arachidonic acid secretion
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of icosanoid secretion
positive regulation of fatty acid transport
regulation of icosanoid secretion
neuropeptide binding
negative regulation of cAMP-mediated signaling
regulation of fatty acid transport
positive regulation of organic acid transport
negative regulation of G protein-coupled receptor signaling pathway
regulation of cAMP-mediated signaling
positive regulation of anion transport
peptide binding
cellular response to glucocorticoid stimulus
regulation of organic acid transport
cellular response to corticosteroid stimulus
positive regulation of lipid transport
positive regulation of lipid localization
regulation of anion transport
neuropeptide signaling pathway
regulation of lipid transport
regulation of lipid localization
regulation of G protein-coupled receptor signaling pathway
response to glucocorticoid
response to corticosteroid
hormone-mediated signaling pathway
cellular response to steroid hormone stimulus
positive regulation of ERK1 and ERK2 cascade
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of ion transport
regulation of ERK1 and ERK2 cascade
response to steroid hormone
forebrain development
positive regulation of secretion
negative regulation of intracellular signal transduction