ST13

Entrez Summary: N/A
UniProt Summary: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dATP binding
negative regulation of protein refolding
regulation of protein refolding
negative regulation of protein folding
regulation of protein folding
chaperone cofactor-dependent protein refolding
de novo posttranslational protein folding
de novo protein folding
Hsp70 protein binding
chaperone-mediated protein folding
protein binding, bridging
protein homotetramerization
chaperone binding
unfolded protein binding
protein tetramerization
protein dimerization activity
protein folding
protein domain specific binding
protein-containing complex binding
protein homooligomerization
protein complex oligomerization
protein-containing complex
response to bacterium
identical protein binding
response to other organism
response to external biotic stimulus
response to biotic stimulus
protein-containing complex assembly
protein-containing complex subunit organization