ST14

Entrez Summary: The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008].
UniProt Summary: Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. {ECO:0000269|PubMed:18843291}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.93
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.72
Olaparib 4μM R08 exp512	-1.72

epithelial cell morphogenesis involved in placental branching
epithelial cell differentiation involved in embryonic placenta development
branching involved in labyrinthine layer morphogenesis
labyrinthine layer morphogenesis
embryonic placenta morphogenesis
cell differentiation involved in embryonic placenta development
extrinsic component of plasma membrane
epithelial cell morphogenesis
labyrinthine layer development
serine-type peptidase activity
embryonic placenta development
neural tube closure
tube closure
primary neural tube formation
neural tube formation
cornification
embryonic epithelial tube formation
epithelial tube formation
morphogenesis of embryonic epithelium
tube formation
placenta development
morphogenesis of a branching epithelium
neural tube development
serine-type endopeptidase activity
morphogenesis of a branching structure
epithelial cell development
basolateral plasma membrane
keratinization
keratinocyte differentiation
epithelial tube morphogenesis
epidermal cell differentiation
in utero embryonic development
skin development
epidermis development
reproductive structure development
reproductive system development
morphogenesis of an epithelium
embryonic organ development
cell morphogenesis involved in differentiation
tissue morphogenesis