ST20 [The Human Chemical-Genetic Interaction Map Project]

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======= ST20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ST20
  * **<color #00a2e8>Official Name</color>**: suppressor of tumorigenicity 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=400410|400410]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HBF5|Q9HBF5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ST20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ST20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a tumor suppressor. Promotes apoptosis of cancer cells. {ECO:0000269|PubMed:11857354}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of apoptotic DNA fragmentation|
|positive regulation of DNA catabolic process|
|cellular response to UV-C|
|regulation of apoptotic DNA fragmentation|
|regulation of DNA catabolic process|
|positive regulation of execution phase of apoptosis|
|cysteine-type endopeptidase activator activity involved in apoptotic process|
|response to UV-C|
|regulation of execution phase of apoptosis|
|cellular response to UV|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to light stimulus|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|response to UV|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of endopeptidase activity|
|cellular response to radiation|
|negative regulation of cell growth|
|positive regulation of peptidase activity|
|positive regulation of DNA metabolic process|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of growth|
|apoptotic signaling pathway|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of DNA metabolic process|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of cell growth|
|regulation of endopeptidase activity|
|positive regulation of catabolic process|
|response to radiation|
|regulation of peptidase activity|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of growth|
|positive regulation of cell death|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|regulation of cellular catabolic process|
|apoptotic process|
|regulation of catabolic process|
|programmed cell death|
|cell death|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.07|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.01|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.99|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.98|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.93|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.9|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.7|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.71|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.72|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.74|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.78|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.78|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.79|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.93|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.99|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.03|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|2.03|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|2.06|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.07|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.08|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14279
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ST20 Expression in NALM6 Cells: 1.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>