ST20

Gene Information

Official Symbol: ST20
Official Name: suppressor of tumorigenicity 20
Aliases and Previous Symbols: N/A
Entrez ID: 400410
UniProt: Q9HBF5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: May act as a tumor suppressor. Promotes apoptosis of cancer cells. {ECO:0000269|PubMed:11857354}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Parthenolide 2.5μM R05 exp238	-2.07
NFN1 0.1μM R01 exp49	-2.01
AICAR 240μM R05 exp211	-1.99
Cerivastatin 0.15μM R05 exp226	-1.98
Ribavirin 10μM R01 exp52	-1.93
Disulfiram 4.3μM R06 exp281	-1.9
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	1.7
Nicotinamide 1000μM R03 exp101	1.71
Beta-Estradiol 0.55μM R07 exp425	1.72
CCCP 1μM R00 exp11	1.74
Dynasore 7μM R08 exp436	1.78
VHL-ligand-1 20μM R07 exp421	1.78
GSK-J4 1μM R07 exp362	1.79
Pomalidomide 20μM R07 exp391	1.93
CoCl2 18μM R07 exp346	1.99
MLN-4924 0.2μM R00 exp21	2.03
Oligomycin-A 20μM R00 exp26	2.03
Brefeldin A 0.02μM R00 exp8	2.06
Alpha-Amanitin 0.5μM R00 exp5	2.07
I-BRD9 4μM R07 exp365	2.08
Bortezomib 0.05μM R00 exp7	2.54

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14279
Expression level (log2 read counts): 1.44

Expression Distribution

positive regulation of apoptotic DNA fragmentation
positive regulation of DNA catabolic process
cellular response to UV-C
regulation of apoptotic DNA fragmentation
regulation of DNA catabolic process
positive regulation of execution phase of apoptosis
cysteine-type endopeptidase activator activity involved in apoptotic process
response to UV-C
regulation of execution phase of apoptosis
cellular response to UV
activation of cysteine-type endopeptidase activity involved in apoptotic process
cellular response to light stimulus
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to UV
positive regulation of cysteine-type endopeptidase activity
positive regulation of endopeptidase activity
cellular response to radiation
negative regulation of cell growth
positive regulation of peptidase activity
positive regulation of DNA metabolic process
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity
negative regulation of growth
apoptotic signaling pathway
response to light stimulus
cellular response to environmental stimulus
cellular response to abiotic stimulus
regulation of DNA metabolic process
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of cell growth
regulation of endopeptidase activity
positive regulation of catabolic process
response to radiation
regulation of peptidase activity
positive regulation of apoptotic process
positive regulation of programmed cell death
regulation of growth
positive regulation of cell death
regulation of proteolysis