ST3GAL1

Entrez Summary: N/A
UniProt Summary: Responsible for the synthesis of the sequence NeuAc- alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values. {ECO:0000250|UniProtKB:P54751}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
N-acetylneuraminate metabolic process
sialylation
keratan sulfate biosynthetic process
keratan sulfate metabolic process
amino sugar metabolic process
O-glycan processing
protein N-linked glycosylation
Golgi cisterna membrane
glycosaminoglycan biosynthetic process
antibiotic metabolic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
protein O-linked glycosylation
glycosaminoglycan metabolic process
aminoglycan metabolic process
sulfur compound biosynthetic process
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
sulfur compound metabolic process
glycoprotein metabolic process
drug metabolic process
Golgi membrane
carbohydrate derivative biosynthetic process
carboxylic acid metabolic process
protein phosphorylation
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
phosphorylation
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
membrane