ST3GAL4

Entrez Summary: This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
UniProt Summary: Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta- 1,4-GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. {ECO:0000250|UniProtKB:Q91Y74, ECO:0000269|PubMed:8611500}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

monosialoganglioside sialyltransferase activity
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
protein sialylation
lipid glycosylation
sialyltransferase activity
oligosaccharide biosynthetic process
sialylation
keratan sulfate biosynthetic process
keratan sulfate metabolic process
oligosaccharide metabolic process
O-glycan processing
glycolipid biosynthetic process
Golgi cisterna membrane
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
glycolipid metabolic process
liposaccharide metabolic process
protein O-linked glycosylation
carbohydrate biosynthetic process
membrane lipid biosynthetic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
sulfur compound biosynthetic process
lipid modification
membrane lipid metabolic process
protein glycosylation
macromolecule glycosylation
glycosylation
cognition
glycoprotein biosynthetic process
sulfur compound metabolic process
glycoprotein metabolic process
carbohydrate metabolic process
lipid biosynthetic process
Golgi membrane
carbohydrate derivative biosynthetic process
cellular lipid metabolic process
oxoacid metabolic process
organic acid metabolic process