STAC2

Gene Information

Official Symbol: STAC2
Official Name: SH3 and cysteine rich domain 2
Aliases and Previous Symbols: N/A
Entrez ID: 342667
UniProt: Q6ZMT1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein containing an SH3 domain and a zinc finger domain. The encoded protein has been shown to regulate calcium channel inactivation in a human cell line. Reduced expression of this gene has been observed in human heart failure. [provided by RefSeq, May 2017].
UniProt Summary: Slows down the inactivation rate of the calcium channel CACNA1C. {ECO:0000250|UniProtKB:Q8R1B0}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vinblastine 0.015μM R05 exp208	-2.12
Tubastatin-A 2.5μM R07 exp417	-1.76
Disulfiram 4.3μM R06 exp281	-1.74
ONC212 0.15μM R08 exp513	-1.71
Bisphenol S 100μM R08 exp458	2.05
Celastrol 0.12μM R05 exp225	2.18

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3049
Expression level (log2 read counts): 2.19

Expression Distribution

SH3 2
SH3 1
C1 1

positive regulation of voltage-gated calcium channel activity
skeletal muscle contraction
regulation of voltage-gated calcium channel activity
positive regulation of calcium ion transmembrane transporter activity
musculoskeletal movement
multicellular organismal movement
positive regulation of protein localization to plasma membrane
extrinsic component of cytoplasmic side of plasma membrane
positive regulation of protein localization to cell periphery
positive regulation of cation channel activity
positive regulation of calcium ion transmembrane transport
regulation of calcium ion transmembrane transporter activity
regulation of protein localization to plasma membrane
sarcolemma
positive regulation of ion transmembrane transporter activity
striated muscle contraction
positive regulation of transporter activity
regulation of protein localization to cell periphery
positive regulation of calcium ion transport
positive regulation of protein localization to membrane
positive regulation of cation transmembrane transport
regulation of calcium ion transmembrane transport
positive regulation of ion transmembrane transport
regulation of cation channel activity
regulation of protein localization to membrane
positive regulation of transmembrane transport
regulation of calcium ion transport
muscle contraction
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
positive regulation of ion transport
regulation of transporter activity
muscle system process
positive regulation of cellular protein localization
regulation of cation transmembrane transport
regulation of metal ion transport
regulation of ion transmembrane transport
regulation of cellular protein localization
regulation of transmembrane transport
regulation of ion transport