STAG2 [The Human Chemical-Genetic Interaction Map Project]

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======= STAG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STAG2
  * **<color #00a2e8>Official Name</color>**: stromal antigen 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10735|10735]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N3U4|Q8N3U4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STAG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STAG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300826|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. {ECO:0000269|PubMed:12034751}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|STAG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of DNA endoreduplication|
|regulation of DNA endoreduplication|
|cohesin complex|
|regulation of mitotic spindle assembly|
|negative regulation of DNA-dependent DNA replication|
|mitotic spindle pole|
|regulation of spindle assembly|
|regulation of mitotic spindle organization|
|negative regulation of DNA replication|
|regulation of spindle organization|
|sister chromatid cohesion|
|regulation of DNA-dependent DNA replication|
|chromosome, centromeric region|
|regulation of DNA replication|
|nuclear matrix|
|chromatin|
|chromosome|
|sister chromatid segregation|
|regulation of mitotic nuclear division|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|nuclear chromosome segregation|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|meiotic cell cycle|
|chromosome segregation|
|negative regulation of cell cycle process|
|chromatin binding|
|cell division|
|regulation of cytoskeleton organization|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|regulation of cell cycle process|
|regulation of cellular component biogenesis|
|cell cycle process|
|chromosome organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.68|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.68|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.52|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.12|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.07|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.03|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.99|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.96|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.93|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.9|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.89|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.87|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.87|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.86|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.82|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.8|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.8|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.77|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.77|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.75|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.75|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.74|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.73|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.72|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.72|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-1.71|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.7|
|[[:results:exp303|39°C R06 exp303]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:asb3|ASB3]]|0.493|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 66/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|7/26|
|bone|0/26|
|breast|4/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|2/17|
|esophagus|3/11|
|fibroblast|0/1|
|gastric|2/14|
|kidney|1/18|
|liver|5/19|
|lung|2/72|
|lymphocyte|1/16|
|ovary|0/25|
|pancreas|2/22|
|peripheral nervous system|3/15|
|plasma cell|2/12|
|prostate|1/1|
|skin|5/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|2/28|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8734
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STAG2 Expression in NALM6 Cells: 8.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>