STAG2

Entrez Summary: The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].
UniProt Summary: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. {ECO:0000269|PubMed:12034751}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
I-BRD9 4μM R07 exp365	-2.68
Milciclib 2μM R08 exp502	-2.68
Pimelic-diphenylamide-106 0.5μM R00 exp27	-2.52
2-Methoxyestradiol 0.55μM R07 exp310	-2.12
Lead acetate 2000μM R08 exp498 no dilution day6	-2.07
Radicicol 0.16μM R05 exp242	-2.03
Dexamethasone 0.006μM R07 exp351	-1.99
All-trans-Retinoic-Acid 8μM R07 exp333	-1.96
Genistein 15μM R07 exp360	-1.93
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.9
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.89
Selumetinib 20μM R02 exp81	-1.87
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-1.87
BAY-598 4μM R05 exp220	-1.86
YM155 0.0002μM R01 exp61	-1.82
BI-D1870 3.15μM R02 exp66	-1.8
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.8
Nutlin-3A 1.6μM R06 exp294	-1.77
Pomalidomide 20μM R07 exp391	-1.77
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.75
Ribavirin 10μM R01 exp52	-1.75
Latrunculin-B 10μM R07 exp374	-1.74
Thioridazine 5μM R08 exp530	-1.73
Chlorpromazine 10μM R07 exp344	-1.72
TNF-alpha 44ng/ml R08 exp533	-1.72
Pyrazinamide 100μM R08 exp516	-1.71
UM0011500 10μM R05 exp246	-1.7
39°C R06 exp303	1.74

Global Fraction of Cell Lines Where Essential: 66/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	7/26
bone	0/26
breast	4/30
central nervous system	0/49
cervix	0/4
colorectal	2/17
esophagus	3/11
fibroblast	0/1
gastric	2/14
kidney	1/18
liver	5/19
lung	2/72
lymphocyte	1/16
ovary	0/25
pancreas	2/22
peripheral nervous system	3/15
plasma cell	2/12
prostate	1/1
skin	5/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	2/28
uterus	1/5

Expression Distribution

negative regulation of DNA endoreduplication
regulation of DNA endoreduplication
cohesin complex
regulation of mitotic spindle assembly
negative regulation of DNA-dependent DNA replication
mitotic spindle pole
regulation of spindle assembly
regulation of mitotic spindle organization
negative regulation of DNA replication
regulation of spindle organization
sister chromatid cohesion
regulation of DNA-dependent DNA replication
chromosome, centromeric region
regulation of DNA replication
nuclear matrix
chromatin
chromosome
sister chromatid segregation
regulation of mitotic nuclear division
regulation of microtubule cytoskeleton organization
regulation of nuclear division
nuclear chromosome segregation
regulation of organelle assembly
regulation of microtubule-based process
meiotic cell cycle
chromosome segregation
negative regulation of cell cycle process
chromatin binding
cell division
regulation of cytoskeleton organization
negative regulation of cell cycle
regulation of mitotic cell cycle
regulation of cell cycle process
regulation of cellular component biogenesis
cell cycle process
chromosome organization
regulation of cell cycle
regulation of organelle organization
cell cycle
negative regulation of cellular macromolecule biosynthetic process