STAP2

Entrez Summary: N/A
UniProt Summary: Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity. {ECO:0000269|PubMed:10980601}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
PU-H71 1μM R08 exp515	-1.87
DABN 2μM R00 exp16	1.8

signaling adaptor activity
positive regulation of tyrosine phosphorylation of STAT protein
regulation of tyrosine phosphorylation of STAT protein
positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of receptor signaling pathway via STAT
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
positive regulation of peptidyl-tyrosine phosphorylation
regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein phosphorylation
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
positive regulation of protein modification process
regulation of protein phosphorylation
regulation of phosphorylation
positive regulation of cellular protein metabolic process
positive regulation of signal transduction
positive regulation of protein metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
positive regulation of cell communication
positive regulation of signaling
regulation of protein modification process