STARD7 [The Human Chemical-Genetic Interaction Map Project]

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======= STARD7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STARD7
  * **<color #00a2e8>Official Name</color>**: StAR related lipid transfer domain containing 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56910|56910]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQZ5|Q9NQZ5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STARD7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STARD7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616712|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a protective role in mucosal tissues by preventing exaggerated allergic responses. {ECO:0000250|UniProtKB:Q8R1R3}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|START|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phospholipid transporter activity|
|phosphatidylcholine biosynthetic process|
|phosphatidylcholine metabolic process|
|phospholipid transport|
|organophosphate ester transport|
|lipid binding|
|mitochondrial outer membrane|
|ammonium ion metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|lipid transport|
|glycerophospholipid metabolic process|
|lipid localization|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organic anion transport|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|anion transport|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|lipid metabolic process|
|ion transport|
|organonitrogen compound biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-3.29|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-2.89|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.86|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.49|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.26|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.96|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.96|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.95|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.83|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.8|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.77|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.77|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.74|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.72|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.7|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.71|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.71|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.76|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.81|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.82|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.83|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.83|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.91|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.96|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.99|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.05|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.19|
|[[:results:exp518|RK-33 8μM R08 exp518]]|2.2|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.4|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.54|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.68|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.81|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|3.38|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|3.53|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|3.6|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|4.2|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|4.92|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|5.41|
|[[:results:exp359|FK-506 30μM R07 exp359]]|6.06|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|8.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.454|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 24/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15966
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.38 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STARD7 Expression in NALM6 Cells: 8.38'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>