STAT4

Gene Information

Official Symbol: STAT4
Official Name: signal transducer and activator of transcription 4
Aliases and Previous Symbols: N/A
Entrez ID: 6775
UniProt: Q14765
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011].
UniProt Summary: Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8861
Expression level (log2 read counts): 1.41

Expression Distribution

Screen	Score
Temozolomide 200μM R04 exp189	1.93
Apcin 50 to 100μM on day4 R04 exp176	2.1

STAT alpha
STAT int
SH2
STAT bind

interleukin-21-mediated signaling pathway
response to interleukin-21
cellular response to interleukin-21
interleukin-23-mediated signaling pathway
interleukin-35-mediated signaling pathway
receptor signaling pathway via JAK-STAT
receptor signaling pathway via STAT
interleukin-12-mediated signaling pathway
cellular response to interleukin-12
response to interleukin-12
response to peptide hormone
DNA-binding transcription activator activity, RNA polymerase II-specific
response to peptide
RNA polymerase II proximal promoter sequence-specific DNA binding
cytokine-mediated signaling pathway
DNA-binding transcription factor activity
response to hormone
response to organonitrogen compound
cellular response to cytokine stimulus
identical protein binding
response to nitrogen compound
response to cytokine
positive regulation of transcription by RNA polymerase II
defense response
response to endogenous stimulus
positive regulation of transcription, DNA-templated
response to oxygen-containing compound
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of cell population proliferation
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process