STAT6 [The Human Chemical-Genetic Interaction Map Project]

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======= STAT6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STAT6
  * **<color #00a2e8>Official Name</color>**: signal transducer and activator of transcription 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6778|6778]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42226|P42226]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STAT6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STAT6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601512|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269|PubMed:17210636}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|STAT int|
|STAT alpha|
|STAT bind|
|SH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|T-helper 1 cell lineage commitment|
|positive regulation of isotype switching to IgE isotypes|
|interleukin-4-mediated signaling pathway|
|regulation of isotype switching to IgE isotypes|
|T-helper 1 cell differentiation|
|T-helper cell lineage commitment|
|CD4-positive, alpha-beta T cell lineage commitment|
|mammary gland epithelial cell proliferation|
|alpha-beta T cell lineage commitment|
|negative regulation of type 2 immune response|
|growth hormone receptor signaling pathway via JAK-STAT|
|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|
|T-helper 1 type immune response|
|cellular response to reactive nitrogen species|
|growth hormone receptor signaling pathway|
|T cell lineage commitment|
|cellular response to growth hormone stimulus|
|positive regulation of isotype switching|
|positive T cell selection|
|T-helper cell differentiation|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|alpha-beta T cell differentiation involved in immune response|
|alpha-beta T cell activation involved in immune response|
|cellular response to interleukin-4|
|regulation of type 2 immune response|
|response to interleukin-4|
|T cell differentiation involved in immune response|
|regulation of isotype switching|
|response to growth hormone|
|CD4-positive, alpha-beta T cell differentiation|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of B cell mediated immunity|
|receptor signaling pathway via JAK-STAT|
|CD4-positive, alpha-beta T cell activation|
|T cell selection|
|positive regulation of DNA recombination|
|receptor signaling pathway via STAT|
|mammary gland morphogenesis|
|positive regulation of immunoglobulin production|
|alpha-beta T cell differentiation|
|regulation of B cell mediated immunity|
|regulation of immunoglobulin mediated immune response|
|mammary gland epithelium development|
|alpha-beta T cell activation|
|regulation of immunoglobulin production|
|T cell activation involved in immune response|
|cellular response to hydrogen peroxide|
|positive regulation of type I interferon production|
|protein phosphatase binding|
|epithelial cell proliferation|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of cold-induced thermogenesis|
|gland morphogenesis|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of DNA recombination|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|lymphocyte activation involved in immune response|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|regulation of type I interferon production|
|mammary gland development|
|cellular response to reactive oxygen species|
|positive regulation of leukocyte mediated immunity|
|T cell differentiation|
|regulation of production of molecular mediator of immune response|
|regulation of cold-induced thermogenesis|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|regulation of adaptive immune response|
|positive regulation of B cell activation|
|positive regulation of DNA metabolic process|
|response to reactive oxygen species|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|cellular response to toxic substance|
|positive regulation of immune effector process|
|membrane raft|
|T cell activation|
|lymphocyte differentiation|
|nuclear chromatin|
|nuclear membrane|
|cellular response to oxidative stress|
|cell fate commitment|
|cellular response to peptide hormone stimulus|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|response to antibiotic|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|cellular response to peptide|
|leukocyte differentiation|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|response to oxidative stress|
|response to peptide hormone|
|cellular response to drug|
|positive regulation of leukocyte activation|
|gland development|
|positive regulation of cell activation|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of cytokine production|
|regulation of immune effector process|
|response to peptide|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|response to inorganic substance|
|cell population proliferation|
|hemopoiesis|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|immune system development|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|DNA-binding transcription factor activity|
|regulation of cytokine production|
|enzyme linked receptor protein signaling pathway|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|response to hormone|
|leukocyte activation|
|animal organ morphogenesis|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|cellular response to oxygen-containing compound|
|identical protein binding|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|response to cytokine|
|epithelium development|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|defense response|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-2.35|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.82|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.77|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.76|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.71|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9411
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STAT6 Expression in NALM6 Cells: 7.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>