STAT6
Gene Information
- Official Symbol: STAT6
- Official Name: signal transducer and activator of transcription 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 6778
- UniProt: P42226
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
- UniProt Summary: Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269|PubMed:17210636}.
Pfam Domains GO Terms
Pfam Domains
| STAT int |
| STAT alpha |
| STAT bind |
| SH2 |
GO Terms
| T-helper 1 cell lineage commitment |
| positive regulation of isotype switching to IgE isotypes |
| interleukin-4-mediated signaling pathway |
| regulation of isotype switching to IgE isotypes |
| T-helper 1 cell differentiation |
| T-helper cell lineage commitment |
| CD4-positive, alpha-beta T cell lineage commitment |
| mammary gland epithelial cell proliferation |
| alpha-beta T cell lineage commitment |
| negative regulation of type 2 immune response |
| growth hormone receptor signaling pathway via JAK-STAT |
| CD4-positive or CD8-positive, alpha-beta T cell lineage commitment |
| T-helper 1 type immune response |
| cellular response to reactive nitrogen species |
| growth hormone receptor signaling pathway |
| T cell lineage commitment |
| cellular response to growth hormone stimulus |
| positive regulation of isotype switching |
| positive T cell selection |
| T-helper cell differentiation |
| CD4-positive, alpha-beta T cell differentiation involved in immune response |
| alpha-beta T cell differentiation involved in immune response |
| alpha-beta T cell activation involved in immune response |
| cellular response to interleukin-4 |
| regulation of type 2 immune response |
| response to interleukin-4 |
| T cell differentiation involved in immune response |
| regulation of isotype switching |
| response to growth hormone |
| CD4-positive, alpha-beta T cell differentiation |
| positive regulation of immunoglobulin mediated immune response |
| positive regulation of B cell mediated immunity |
| receptor signaling pathway via JAK-STAT |
| CD4-positive, alpha-beta T cell activation |
| T cell selection |
| positive regulation of DNA recombination |
| receptor signaling pathway via STAT |
| mammary gland morphogenesis |
| positive regulation of immunoglobulin production |
| alpha-beta T cell differentiation |
| regulation of B cell mediated immunity |
| regulation of immunoglobulin mediated immune response |
| mammary gland epithelium development |
| alpha-beta T cell activation |
| regulation of immunoglobulin production |
| T cell activation involved in immune response |
| cellular response to hydrogen peroxide |
| positive regulation of type I interferon production |
| protein phosphatase binding |
| epithelial cell proliferation |
| positive regulation of production of molecular mediator of immune response |
| positive regulation of cold-induced thermogenesis |
| gland morphogenesis |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of DNA recombination |
| positive regulation of lymphocyte mediated immunity |
| positive regulation of adaptive immune response |
| lymphocyte activation involved in immune response |
| cellular response to antibiotic |
| response to hydrogen peroxide |
| regulation of type I interferon production |
| mammary gland development |
| cellular response to reactive oxygen species |
| positive regulation of leukocyte mediated immunity |
| T cell differentiation |
| regulation of production of molecular mediator of immune response |
| regulation of cold-induced thermogenesis |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of immune response |
| regulation of lymphocyte mediated immunity |
| regulation of adaptive immune response |
| positive regulation of B cell activation |
| positive regulation of DNA metabolic process |
| response to reactive oxygen species |
| regulation of leukocyte mediated immunity |
| regulation of B cell activation |
| cellular response to toxic substance |
| positive regulation of immune effector process |
| membrane raft |
| T cell activation |
| lymphocyte differentiation |
| nuclear chromatin |
| nuclear membrane |
| cellular response to oxidative stress |
| cell fate commitment |
| cellular response to peptide hormone stimulus |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| response to antibiotic |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| cellular response to peptide |
| leukocyte differentiation |
| regulation of DNA metabolic process |
| positive regulation of lymphocyte activation |
| lymphocyte activation |
| response to oxidative stress |
| response to peptide hormone |
| cellular response to drug |
| positive regulation of leukocyte activation |
| gland development |
| positive regulation of cell activation |
| negative regulation of immune system process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| positive regulation of cytokine production |
| regulation of immune effector process |
| response to peptide |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| response to toxic substance |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of lymphocyte activation |
| response to inorganic substance |
| cell population proliferation |
| hemopoiesis |
| cellular response to organonitrogen compound |
| regulation of leukocyte activation |
| cellular response to hormone stimulus |
| hematopoietic or lymphoid organ development |
| adaptive immune response |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| immune system development |
| cellular response to nitrogen compound |
| cytokine-mediated signaling pathway |
| DNA-binding transcription factor activity |
| regulation of cytokine production |
| enzyme linked receptor protein signaling pathway |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of immune response |
| response to hormone |
| leukocyte activation |
| animal organ morphogenesis |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| response to drug |
| cellular response to oxygen-containing compound |
| identical protein binding |
| cell activation |
| response to nitrogen compound |
| immune effector process |
| response to cytokine |
| epithelium development |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| defense response |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| cellular response to stress |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| S-DABN 8μM R03 exp112 | -2.35 |
| WYE-354 6μM R02 exp90 | -1.82 |
| Myriocin 25μM R06 exp293 | -1.77 |
| ABT-702 5μM plus CoCl2 18μM R07 exp320 | -1.76 |
| Artemisinin 50μM R08 exp450 | 1.71 |
| ABT-702 5μM plus Deferoxamine 11μM R07 exp321 | 2.03 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9411
- Expression level (log2 read counts): 7.61
Expression Distribution
STAT6 Expression in NALM6 Cells: 7.61
