STK24

Entrez Summary: N/A
UniProt Summary: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. {ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825, ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762, ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Mdivi-1 15μM R05 exp217	1.8
BVD-523 15μM R02 exp67	2.24

Pkinase
Pkinase Tyr

intrinsic apoptotic signaling pathway in response to oxidative stress
cell death in response to oxidative stress
regulation of axon regeneration
regulation of neuron projection regeneration
execution phase of apoptosis
response to hydrogen peroxide
stress-activated protein kinase signaling cascade
intrinsic apoptotic signaling pathway
cellular response to starvation
regulation of response to wounding
protein autophosphorylation
response to starvation
response to reactive oxygen species
cellular response to nutrient levels
protein kinase activity
cellular response to oxidative stress
negative regulation of cell migration
cellular response to extracellular stimulus
negative regulation of cell motility
apoptotic signaling pathway
response to antibiotic
negative regulation of cellular component movement
cadherin binding
negative regulation of locomotion
activation of protein kinase activity
cellular response to external stimulus
protein serine/threonine kinase activity
MAPK cascade
response to oxidative stress
signal transduction by protein phosphorylation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
regulation of neuron projection development
response to nutrient levels
response to toxic substance
cell part morphogenesis
response to extracellular stimulus
positive regulation of protein kinase activity
response to inorganic substance