STK33

Entrez Summary: N/A
UniProt Summary: Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines. {ECO:0000250, ECO:0000269|PubMed:21742770}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

mitotic DNA damage checkpoint
signal transduction in response to DNA damage
mitotic DNA integrity checkpoint
DNA damage checkpoint
DNA integrity checkpoint
mitotic cell cycle checkpoint
cell cycle checkpoint
protein autophosphorylation
negative regulation of mitotic cell cycle
protein serine/threonine kinase activity
negative regulation of cell cycle
mitotic cell cycle process
regulation of mitotic cell cycle
mitotic cell cycle
perinuclear region of cytoplasm
cellular response to DNA damage stimulus
protein phosphorylation
cell cycle process
regulation of cell cycle
phosphorylation
cell cycle
ATP binding
intracellular signal transduction
cellular response to stress