STK36

Gene Information

Official Symbol: STK36
Official Name: serine/threonine kinase 36
Aliases and Previous Symbols: N/A
Entrez ID: 27148
UniProt: Q9NRP7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011].
UniProt Summary: Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (By similarity). Essential for construction of the central pair apparatus of motile cilia. {ECO:0000250|UniProtKB:Q69ZM6, ECO:0000269|PubMed:10806483}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6447
Expression level (log2 read counts): 3.92

Expression Distribution

Screen	Score
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-2.21
AICAR 240μM R05 exp211	-2.01
Doxycycline 10μM R00 exp18	2.46

Pkinase Tyr
Pkinase

positive regulation of hh target transcription factor activity
signal transduction downstream of smoothened
epithelial cilium movement involved in extracellular fluid movement
extracellular transport
positive regulation of smoothened signaling pathway
cilium movement
smoothened signaling pathway
regulation of smoothened signaling pathway
post-embryonic development
microtubule-based transport
positive regulation of DNA-binding transcription factor activity
microtubule-based movement
transcription factor binding
cilium assembly
protein serine/threonine kinase activity
cilium organization
regulation of DNA-binding transcription factor activity
plasma membrane bounded cell projection assembly
cell projection assembly
microtubule-based process
brain development
organelle assembly
head development
protein phosphorylation
central nervous system development
plasma membrane bounded cell projection organization
cell projection organization
phosphorylation
ATP binding
movement of cell or subcellular component
positive regulation of signal transduction
intracellular signal transduction
positive regulation of molecular function
positive regulation of cell communication
positive regulation of signaling
extracellular region