STMN2

Gene Information

Official Symbol: STMN2
Official Name: stathmin 2
Aliases and Previous Symbols: N/A
Entrez ID: 11075
UniProt: Q93045
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10083
Expression level (log2 read counts): -3.02

Expression Distribution

positive regulation of microtubule depolymerization
negative regulation of microtubule polymerization
microtubule depolymerization
positive regulation of protein depolymerization
negative regulation of microtubule depolymerization
regulation of microtubule depolymerization
positive regulation of microtubule polymerization or depolymerization
protein depolymerization
positive regulation of protein complex disassembly
negative regulation of microtubule polymerization or depolymerization
cellular response to nerve growth factor stimulus
microtubule polymerization or depolymerization
regulation of microtubule polymerization
response to nerve growth factor
tubulin binding
negative regulation of protein depolymerization
calcium-dependent protein binding
negative regulation of protein polymerization
negative regulation of protein complex disassembly
regulation of microtubule polymerization or depolymerization
regulation of protein depolymerization
regulation of protein complex disassembly
growth cone
negative regulation of protein complex assembly
negative regulation of supramolecular fiber organization
cellular protein complex disassembly
negative regulation of cytoskeleton organization
negative regulation of neuron projection development
lamellipodium
negative regulation of cell projection organization
regulation of microtubule cytoskeleton organization
positive regulation of supramolecular fiber organization
positive regulation of cytoskeleton organization
regulation of microtubule-based process
regulation of protein polymerization
negative regulation of neuron differentiation
protein-containing complex disassembly
endosome
positive regulation of neuron projection development
negative regulation of neurogenesis