STMN3

Entrez Summary: N/A
UniProt Summary: Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
D-Fructose 10000μM R06 exp279	-1.91
Demecolcine 0.03μM R05 exp228	2.02

negative regulation of Rac protein signal transduction
regulation of Rac protein signal transduction
microtubule depolymerization
hatching
organism emergence from protective structure
blastocyst hatching
protein depolymerization
microtubule polymerization or depolymerization
negative regulation of Ras protein signal transduction
cytoplasmic microtubule organization
tubulin binding
negative regulation of small GTPase mediated signal transduction
regulation of microtubule polymerization or depolymerization
blastocyst development
growth cone
cellular protein complex disassembly
regulation of microtubule cytoskeleton organization
regulation of microtubule-based process
protein-containing complex disassembly
regulation of Ras protein signal transduction
protein domain specific binding
neuron projection
regulation of small GTPase mediated signal transduction
in utero embryonic development
cellular component disassembly
supramolecular fiber organization
microtubule cytoskeleton organization
regulation of GTPase activity
negative regulation of intracellular signal transduction
regulation of cytoskeleton organization
chordate embryonic development
embryo development ending in birth or egg hatching
neuron projection development
microtubule-based process
neuron development
embryo development
Golgi apparatus
neuron differentiation
cytoskeleton organization
plasma membrane bounded cell projection organization