STRADB

Entrez Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
UniProt Summary: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). {ECO:0000250, ECO:0000269|PubMed:14517248}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase Tyr
Pkinase

negative regulation of signal transduction in absence of ligand
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
aggresome
regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of extrinsic apoptotic signaling pathway
stress-activated protein kinase signaling cascade
cell cycle arrest
protein export from nucleus
regulation of extrinsic apoptotic signaling pathway
nuclear export
negative regulation of apoptotic signaling pathway
protein kinase activity
nucleocytoplasmic transport
nuclear transport
activation of protein kinase activity
protein serine/threonine kinase activity
MAPK cascade
signal transduction by protein phosphorylation
regulation of apoptotic signaling pathway
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
positive regulation of protein kinase activity
negative regulation of cell cycle
positive regulation of kinase activity
positive regulation of transferase activity
neuron projection development
cell morphogenesis
regulation of protein kinase activity
neuron development
cellular component morphogenesis
regulation of kinase activity
negative regulation of apoptotic process
negative regulation of programmed cell death
protein phosphorylation
regulation of transferase activity
negative regulation of cell death
intracellular protein transport
cell cycle process