STRC

Entrez Summary: This gene encodes a protein that is associated with the hair bundle of the sensory hair cells in the inner ear. The hair bundle is composed of stiff microvilli called stereocilia and is involved with mechanoreception of sound waves. This gene is part of a tandem duplication on chromosome 15; the second copy is a pseudogene. Mutations in this gene cause autosomal recessive non-syndromic deafness. [provided by RefSeq, Jul 2008].
UniProt Summary: Essential to the formation of horizontal top connectors between outer hair cell stereocilia. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

kinocilium
auditory receptor cell stereocilium organization
detection of mechanical stimulus involved in sensory perception of sound
auditory receptor cell morphogenesis
auditory receptor cell development
stereocilium tip
inner ear auditory receptor cell differentiation
inner ear receptor cell stereocilium organization
detection of mechanical stimulus involved in sensory perception
hair cell differentiation
inner ear receptor cell development
neuroepithelial cell differentiation
detection of mechanical stimulus
columnar/cuboidal epithelial cell development
inner ear receptor cell differentiation
mechanoreceptor differentiation
columnar/cuboidal epithelial cell differentiation
inner ear morphogenesis
ear morphogenesis
detection of external stimulus
detection of abiotic stimulus
cell-matrix adhesion
sensory perception of sound
sensory perception of mechanical stimulus
cell-substrate adhesion
epithelial cell development
inner ear development
response to mechanical stimulus
ear development
sensory organ morphogenesis
embryonic organ morphogenesis
epidermal cell differentiation
epidermis development
cell morphogenesis involved in neuron differentiation
embryonic organ development
detection of stimulus involved in sensory perception
sensory organ development
cell morphogenesis involved in differentiation
embryonic morphogenesis
cell surface