STS

Entrez Summary: This gene encodes a multi-pass membrane protein that is localized to the endoplasmic reticulum. It belongs to the sulfatase family and hydrolyzes several 3-beta-hydroxysteroid sulfates, which serve as metabolic precursors for estrogens, androgens, and cholesterol. Mutations in this gene are associated with X-linked ichthyosis (XLI). Alternatively spliced transcript variants resulting from the use of different promoters have been described for this gene (PMID:17601726). [provided by RefSeq, Mar 2016].
UniProt Summary: Conversion of sulfated steroid precursors to estrogens during pregnancy.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

steryl-sulfatase activity
sulfuric ester hydrolase activity
arylsulfatase activity
steroid catabolic process
glycosphingolipid metabolic process
glycolipid metabolic process
liposaccharide metabolic process
sphingolipid metabolic process
female pregnancy
membrane lipid metabolic process
multi-multicellular organism process
lysosome
steroid metabolic process
endosome
lipid catabolic process
endoplasmic reticulum lumen
epidermis development
organic cyclic compound catabolic process
intracellular membrane-bounded organelle
endoplasmic reticulum membrane
cellular lipid metabolic process
Golgi apparatus
multi-organism reproductive process
endoplasmic reticulum
carbohydrate derivative metabolic process
lipid metabolic process
reproductive process
reproduction
tissue development
organic substance catabolic process
membrane