STX3

Entrez Summary: The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
UniProt Summary: Potentially involved in docking of synaptic vesicles at presynaptic active zones.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Syntaxin
SNARE

exocytic insertion of neurotransmitter receptor to postsynaptic membrane
arachidonic acid binding
presynaptic active zone membrane
synaptic vesicle docking
azurophil granule
zymogen granule membrane
specific granule
synaptic vesicle fusion to presynaptic active zone membrane
vesicle fusion to plasma membrane
vacuole
neurotransmitter receptor transport to plasma membrane
positive regulation of protein localization to cell surface
neurotransmitter receptor transport to postsynaptic membrane
establishment of protein localization to postsynaptic membrane
SNAP receptor activity
neurotransmitter receptor transport
protein localization to postsynaptic membrane
regulation of protein localization to cell surface
receptor localization to synapse
vesicle docking involved in exocytosis
regulation of postsynaptic membrane neurotransmitter receptor levels
long-term synaptic potentiation
SNARE complex
positive regulation of protein localization to plasma membrane
positive regulation of protein localization to cell periphery
protein localization to synapse
vesicle docking
synaptic vesicle exocytosis
SNARE binding
exocytic process
vesicle fusion
presynaptic membrane
endomembrane system
organelle membrane fusion
Schaffer collateral - CA1 synapse
postsynapse
vesicle-mediated transport to the plasma membrane
regulation of protein localization to plasma membrane
organelle fusion
melanosome