STX4 [The Human Chemical-Genetic Interaction Map Project]

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======= STX4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STX4
  * **<color #00a2e8>Official Name</color>**: syntaxin 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6810|6810]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12846|Q12846]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STX4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STX4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/186591|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNARE|
|Syntaxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|storage vacuole|
|positive regulation of eosinophil activation|
|sphingomyelin phosphodiesterase activator activity|
|positive regulation of eosinophil degranulation|
|regulation of eosinophil degranulation|
|regulation of eosinophil activation|
|lateral loop|
|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane|
|myelin sheath adaxonal region|
|SNARE complex assembly|
|presynaptic active zone membrane|
|positive regulation of immunoglobulin secretion|
|somatodendritic compartment|
|synaptic vesicle fusion to presynaptic active zone membrane|
|specific granule|
|vacuole|
|vesicle fusion to plasma membrane|
|positive regulation of protein localization to cell surface|
|regulation of immunoglobulin secretion|
|response to hydroperoxide|
|positive regulation of leukocyte degranulation|
|positive regulation of myeloid leukocyte mediated immunity|
|SNAP receptor activity|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|regulation of protein localization to cell surface|
|positive regulation of immunoglobulin production|
|long-term synaptic potentiation|
|SNARE complex|
|regulation of leukocyte degranulation|
|positive regulation of regulated secretory pathway|
|positive regulation of protein localization to plasma membrane|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|regulation of myeloid leukocyte mediated immunity|
|positive regulation of protein localization to cell periphery|
|vesicle docking|
|regulation of immunoglobulin production|
|synaptic vesicle exocytosis|
|SNARE binding|
|exocytic process|
|vesicle fusion|
|positive regulation of insulin secretion|
|phagocytic vesicle membrane|
|presynaptic membrane|
|endomembrane system|
|organelle membrane fusion|
|postsynapse|
|positive regulation of exocytosis|
|regulation of protein localization to plasma membrane|
|organelle fusion|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of peptide hormone secretion|
|post-Golgi vesicle-mediated transport|
|signal release from synapse|
|neurotransmitter secretion|
|regulation of protein localization to cell periphery|
|synaptic vesicle cycle|
|synaptic vesicle|
|positive regulation of protein localization to membrane|
|positive regulation of hormone secretion|
|vesicle-mediated transport in synapse|
|membrane fusion|
|positive regulation of leukocyte mediated immunity|
|positive regulation of chemotaxis|
|regulation of production of molecular mediator of immune response|
|dendritic spine|
|positive regulation of synaptic transmission|
|regulation of extrinsic apoptotic signaling pathway|
|cellular response to interferon-gamma|
|regulation of regulated secretory pathway|
|signal release|
|organelle localization by membrane tethering|
|trans-Golgi network|
|regulation of insulin secretion|
|lamellipodium|
|membrane docking|
|neurotransmitter transport|
|response to interferon-gamma|
|regulation of synaptic plasticity|
|regulation of protein localization to membrane|
|basolateral plasma membrane|
|regulation of leukocyte mediated immunity|
|regulation of peptide hormone secretion|
|regulation of chemotaxis|
|positive regulation of immune effector process|
|regulation of exocytosis|
|regulation of hormone secretion|
|synapse|
|endosome|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|vesicle organization|
|positive regulation of cellular protein localization|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|Golgi vesicle transport|
|response to oxidative stress|
|regulation of apoptotic signaling pathway|
|positive regulation of cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|positive regulation of protein transport|
|positive regulation of secretion|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|regulation of protein secretion|
|regulation of immune effector process|
|regulation of peptide secretion|
|positive regulation of cell migration|
|positive regulation of cell motility|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|organelle localization|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|cell surface|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|innate immune response|
|exocytosis|
|regulation of secretion|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|membrane organization|
|positive regulation of immune response|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|defense response to other organism|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|intracellular protein transport|
|secretion by cell|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|export from cell|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|extracellular space|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.74|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.74|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.85|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.96|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|2.07|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|3.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 34/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|1/28|
|bone|0/26|
|breast|5/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2080
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STX4 Expression in NALM6 Cells: 4.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>