STX4
Gene Information
- Official Symbol: STX4
- Official Name: syntaxin 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 6810
- UniProt: Q12846
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| SNARE |
| Syntaxin |
GO Terms
| storage vacuole |
| positive regulation of eosinophil activation |
| sphingomyelin phosphodiesterase activator activity |
| positive regulation of eosinophil degranulation |
| regulation of eosinophil degranulation |
| regulation of eosinophil activation |
| lateral loop |
| vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane |
| myelin sheath adaxonal region |
| SNARE complex assembly |
| presynaptic active zone membrane |
| positive regulation of immunoglobulin secretion |
| somatodendritic compartment |
| synaptic vesicle fusion to presynaptic active zone membrane |
| specific granule |
| vacuole |
| vesicle fusion to plasma membrane |
| positive regulation of protein localization to cell surface |
| regulation of immunoglobulin secretion |
| response to hydroperoxide |
| positive regulation of leukocyte degranulation |
| positive regulation of myeloid leukocyte mediated immunity |
| SNAP receptor activity |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| regulation of protein localization to cell surface |
| positive regulation of immunoglobulin production |
| long-term synaptic potentiation |
| SNARE complex |
| regulation of leukocyte degranulation |
| positive regulation of regulated secretory pathway |
| positive regulation of protein localization to plasma membrane |
| regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| regulation of insulin secretion involved in cellular response to glucose stimulus |
| regulation of myeloid leukocyte mediated immunity |
| positive regulation of protein localization to cell periphery |
| vesicle docking |
| regulation of immunoglobulin production |
| synaptic vesicle exocytosis |
| SNARE binding |
| exocytic process |
| vesicle fusion |
| positive regulation of insulin secretion |
| phagocytic vesicle membrane |
| presynaptic membrane |
| endomembrane system |
| organelle membrane fusion |
| postsynapse |
| positive regulation of exocytosis |
| regulation of protein localization to plasma membrane |
| organelle fusion |
| positive regulation of production of molecular mediator of immune response |
| positive regulation of peptide hormone secretion |
| post-Golgi vesicle-mediated transport |
| signal release from synapse |
| neurotransmitter secretion |
| regulation of protein localization to cell periphery |
| synaptic vesicle cycle |
| synaptic vesicle |
| positive regulation of protein localization to membrane |
| positive regulation of hormone secretion |
| vesicle-mediated transport in synapse |
| membrane fusion |
| positive regulation of leukocyte mediated immunity |
| positive regulation of chemotaxis |
| regulation of production of molecular mediator of immune response |
| dendritic spine |
| positive regulation of synaptic transmission |
| regulation of extrinsic apoptotic signaling pathway |
| cellular response to interferon-gamma |
| regulation of regulated secretory pathway |
| signal release |
| organelle localization by membrane tethering |
| trans-Golgi network |
| regulation of insulin secretion |
| lamellipodium |
| membrane docking |
| neurotransmitter transport |
| response to interferon-gamma |
| regulation of synaptic plasticity |
| regulation of protein localization to membrane |
| basolateral plasma membrane |
| regulation of leukocyte mediated immunity |
| regulation of peptide hormone secretion |
| regulation of chemotaxis |
| positive regulation of immune effector process |
| regulation of exocytosis |
| regulation of hormone secretion |
| synapse |
| endosome |
| positive regulation of protein secretion |
| positive regulation of peptide secretion |
| vesicle organization |
| positive regulation of cellular protein localization |
| glutamatergic synapse |
| regulation of neurotransmitter levels |
| Golgi vesicle transport |
| response to oxidative stress |
| regulation of apoptotic signaling pathway |
| positive regulation of cell adhesion |
| positive regulation of secretion by cell |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| positive regulation of protein transport |
| positive regulation of secretion |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| positive regulation of establishment of protein localization |
| synaptic signaling |
| regulation of protein secretion |
| regulation of immune effector process |
| regulation of peptide secretion |
| positive regulation of cell migration |
| positive regulation of cell motility |
| regulation of hormone levels |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| regulation of vesicle-mediated transport |
| positive regulation of locomotion |
| organelle localization |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| cell surface |
| regulation of cell activation |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| perinuclear region of cytoplasm |
| regulated exocytosis |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| innate immune response |
| exocytosis |
| regulation of secretion |
| cellular protein-containing complex assembly |
| regulation of cell migration |
| membrane organization |
| positive regulation of immune response |
| regulation of cell motility |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| defense response to other organism |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| intracellular protein transport |
| secretion by cell |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| export from cell |
| regulation of response to external stimulus |
| response to cytokine |
| cell-cell signaling |
| secretion |
| regulation of immune response |
| positive regulation of immune system process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| positive regulation of catalytic activity |
| protein transport |
| intracellular transport |
| peptide transport |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| extracellular space |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of cell population proliferation |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 34/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 5/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 5/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 3/75 |
| lymphocyte | 0/16 |
| ovary | 2/26 |
| pancreas | 2/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 2/22 |
| urinary tract | 2/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2080
- Expression level (log2 read counts): 4.45
Expression Distribution
STX4 Expression in NALM6 Cells: 4.45
