STXBP3 [The Human Chemical-Genetic Interaction Map Project]

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======= STXBP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STXBP3
  * **<color #00a2e8>Official Name</color>**: syntaxin binding protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6814|6814]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00186|O00186]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STXBP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STXBP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608339|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein to membrane docking|
|tertiary granule|
|negative regulation of calcium ion-dependent exocytosis|
|negative regulation of glucose import|
|specific granule|
|platelet alpha granule|
|negative regulation of glucose transmembrane transport|
|negative regulation of regulated secretory pathway|
|syntaxin-1 binding|
|negative regulation of exocytosis|
|insulin secretion|
|vesicle docking involved in exocytosis|
|regulation of calcium ion-dependent exocytosis|
|platelet aggregation|
|regulation of glucose import|
|syntaxin binding|
|peptide hormone secretion|
|homotypic cell-cell adhesion|
|phagocytic vesicle|
|vesicle docking|
|exocytic process|
|hormone secretion|
|regulation of glucose transmembrane transport|
|hormone transport|
|cellular glucose homeostasis|
|presynapse|
|protein heterooligomerization|
|negative regulation of transmembrane transport|
|platelet activation|
|protein secretion|
|establishment of protein localization to extracellular region|
|cellular response to interferon-gamma|
|regulation of regulated secretory pathway|
|protein localization to extracellular region|
|signal release|
|organelle localization by membrane tethering|
|peptide secretion|
|membrane docking|
|response to interferon-gamma|
|glucose homeostasis|
|carbohydrate homeostasis|
|basolateral plasma membrane|
|negative regulation of secretion by cell|
|regulation of exocytosis|
|response to insulin|
|negative regulation of secretion|
|blood coagulation|
|coagulation|
|hemostasis|
|apical plasma membrane|
|response to peptide hormone|
|response to peptide|
|wound healing|
|negative regulation of transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|neutrophil activation|
|cell-cell adhesion|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|regulation of hormone levels|
|regulation of vesicle-mediated transport|
|regulation of transmembrane transport|
|response to wounding|
|organelle localization|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|brain development|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|innate immune response|
|leukocyte mediated immunity|
|head development|
|exocytosis|
|regulation of secretion|
|cellular homeostasis|
|response to hormone|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|central nervous system development|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|response to cytokine|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.74|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.78|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.8|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|1/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6839
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STXBP3 Expression in NALM6 Cells: 5.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>