STXBP3
Gene Information
- Official Symbol: STXBP3
- Official Name: syntaxin binding protein 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 6814
- UniProt: O00186
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Sec1 |
GO Terms
| protein to membrane docking |
| tertiary granule |
| negative regulation of calcium ion-dependent exocytosis |
| negative regulation of glucose import |
| specific granule |
| platelet alpha granule |
| negative regulation of glucose transmembrane transport |
| negative regulation of regulated secretory pathway |
| syntaxin-1 binding |
| negative regulation of exocytosis |
| insulin secretion |
| vesicle docking involved in exocytosis |
| regulation of calcium ion-dependent exocytosis |
| platelet aggregation |
| regulation of glucose import |
| syntaxin binding |
| peptide hormone secretion |
| homotypic cell-cell adhesion |
| phagocytic vesicle |
| vesicle docking |
| exocytic process |
| hormone secretion |
| regulation of glucose transmembrane transport |
| hormone transport |
| cellular glucose homeostasis |
| presynapse |
| protein heterooligomerization |
| negative regulation of transmembrane transport |
| platelet activation |
| protein secretion |
| establishment of protein localization to extracellular region |
| cellular response to interferon-gamma |
| regulation of regulated secretory pathway |
| protein localization to extracellular region |
| signal release |
| organelle localization by membrane tethering |
| peptide secretion |
| membrane docking |
| response to interferon-gamma |
| glucose homeostasis |
| carbohydrate homeostasis |
| basolateral plasma membrane |
| negative regulation of secretion by cell |
| regulation of exocytosis |
| response to insulin |
| negative regulation of secretion |
| blood coagulation |
| coagulation |
| hemostasis |
| apical plasma membrane |
| response to peptide hormone |
| response to peptide |
| wound healing |
| negative regulation of transport |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| regulation of body fluid levels |
| neutrophil mediated immunity |
| neutrophil activation |
| cell-cell adhesion |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| protein complex oligomerization |
| myeloid cell activation involved in immune response |
| regulation of hormone levels |
| regulation of vesicle-mediated transport |
| regulation of transmembrane transport |
| response to wounding |
| organelle localization |
| myeloid leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulated exocytosis |
| brain development |
| cellular chemical homeostasis |
| regulation of secretion by cell |
| innate immune response |
| leukocyte mediated immunity |
| head development |
| exocytosis |
| regulation of secretion |
| cellular homeostasis |
| response to hormone |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| defense response to other organism |
| central nervous system development |
| response to organonitrogen compound |
| secretion by cell |
| cellular response to cytokine stimulus |
| export from cell |
| cell activation |
| response to nitrogen compound |
| immune effector process |
| response to cytokine |
| chemical homeostasis |
| cell-cell signaling |
| secretion |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| response to endogenous stimulus |
| protein transport |
| peptide transport |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| amide transport |
| establishment of protein localization |
| homeostatic process |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| R-DABN 8μM R03 exp111 | 1.74 |
| Pyridostatin 4μM R05 exp240 | 1.78 |
| Trichostatin-A 0.06μM R07 exp415 | 1.8 |
| Clomiphene 4.4μM R02 exp68 | 2.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 12/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 3/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 2/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 3/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6839
- Expression level (log2 read counts): 5.55
Expression Distribution
STXBP3 Expression in NALM6 Cells: 5.55
