SUCLG2 [The Human Chemical-Genetic Interaction Map Project]

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======= SUCLG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SUCLG2
  * **<color #00a2e8>Official Name</color>**: succinate-CoA ligase GDP-forming subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8801|8801]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96I99|Q96I99]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SUCLG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SUCLG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603922|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. {ECO:0000255|HAMAP- Rule:MF_03221}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ATP-grasp 2|
|Ligase CoA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|succinate-CoA ligase complex (GDP-forming)|
|succinate-CoA ligase complex|
|succinate-CoA ligase (GDP-forming) activity|
|succinate-CoA ligase (ADP-forming) activity|
|succinyl-CoA metabolic process|
|succinate metabolic process|
|tricarboxylic acid cycle|
|GDP binding|
|aerobic respiration|
|thioester metabolic process|
|dicarboxylic acid metabolic process|
|acyl-CoA metabolic process|
|ribonucleoside bisphosphate metabolic process|
|purine nucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|cellular respiration|
|magnesium ion binding|
|energy derivation by oxidation of organic compounds|
|coenzyme metabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|sulfur compound metabolic process|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|GTP binding|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|protein heterodimerization activity|
|drug metabolic process|
|nucleobase-containing small molecule metabolic process|
|cellular amide metabolic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|mitochondrion|
|ATP binding|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18835
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SUCLG2 Expression in NALM6 Cells: -2.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>