SULF2 [The Human Chemical-Genetic Interaction Map Project]

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======= SULF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SULF2
  * **<color #00a2e8>Official Name</color>**: sulfatase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55959|55959]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWU5|Q8IWU5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SULF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SULF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610013|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sulfatase|
|DUF3740|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|esophagus smooth muscle contraction|
|N-acetylglucosamine-6-sulfatase activity|
|gastro-intestinal system smooth muscle contraction|
|glial cell-derived neurotrophic factor receptor signaling pathway|
|glomerular basement membrane development|
|glomerular filtration|
|renal filtration|
|arylsulfatase activity|
|regulation of hepatocyte proliferation|
|negative regulation of fibroblast growth factor receptor signaling pathway|
|glycosaminoglycan binding|
|innervation|
|positive regulation of vascular endothelial growth factor production|
|regulation of fibroblast growth factor receptor signaling pathway|
|liver regeneration|
|regulation of vascular endothelial growth factor production|
|heparan sulfate proteoglycan metabolic process|
|Golgi stack|
|chondrocyte development|
|glomerulus development|
|smooth muscle contraction|
|animal organ regeneration|
|nerve development|
|chondrocyte differentiation|
|proteoglycan metabolic process|
|renal system process|
|nephron development|
|liver development|
|embryonic skeletal system development|
|hepaticobiliary system development|
|positive regulation of canonical Wnt signaling pathway|
|negative regulation of cellular response to growth factor stimulus|
|regeneration|
|cartilage development|
|positive regulation of Wnt signaling pathway|
|bone development|
|connective tissue development|
|muscle contraction|
|regulation of animal organ morphogenesis|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|regulation of canonical Wnt signaling pathway|
|renal system development|
|muscle system process|
|urogenital system development|
|regulation of epithelial cell proliferation|
|extracellular matrix organization|
|regulation of Wnt signaling pathway|
|extracellular structure organization|
|glycoprotein metabolic process|
|gland development|
|positive regulation of cytokine production|
|skeletal system development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to wounding|
|cell surface|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of cytokine production|
|enzyme linked receptor protein signaling pathway|
|calcium ion binding|
|embryo development|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|regulation of anatomical structure morphogenesis|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cell development|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.79|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.78|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.8|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6104
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SULF2 Expression in NALM6 Cells: 1.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>