SULF2

Entrez Summary: N/A
UniProt Summary: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Sulfatase
DUF3740

esophagus smooth muscle contraction
N-acetylglucosamine-6-sulfatase activity
gastro-intestinal system smooth muscle contraction
glial cell-derived neurotrophic factor receptor signaling pathway
glomerular basement membrane development
glomerular filtration
renal filtration
arylsulfatase activity
regulation of hepatocyte proliferation
negative regulation of fibroblast growth factor receptor signaling pathway
glycosaminoglycan binding
innervation
positive regulation of vascular endothelial growth factor production
regulation of fibroblast growth factor receptor signaling pathway
liver regeneration
regulation of vascular endothelial growth factor production
heparan sulfate proteoglycan metabolic process
Golgi stack
chondrocyte development
glomerulus development
smooth muscle contraction
animal organ regeneration
nerve development
chondrocyte differentiation
proteoglycan metabolic process
renal system process
nephron development
liver development
embryonic skeletal system development
hepaticobiliary system development
positive regulation of canonical Wnt signaling pathway
negative regulation of cellular response to growth factor stimulus
regeneration
cartilage development
positive regulation of Wnt signaling pathway
bone development
connective tissue development
muscle contraction
regulation of animal organ morphogenesis
kidney development